Modeling biomarker dynamics with implications for the treatment of prostate cancer

Erin B. Hedican; John T. Kemper; Nicole M. Lanie

doi:10.1080/17486700701349021

Modeling biomarker dynamics with implications for the treatment of prostate cancer

Erin B. Hedican, John T. Kemper, Nicole M. Lanie

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

The authors review existing models of biomarker dynamics and develop and investigate several new models which may better accommodate the underlying biology. While the general foundations of the models studied could be applied to a number of biomarker systems, the parameter values and specific applications to treatment regimens are focused on the role of prostate-specific antigen (PSA) as a biomarker for prostate cancer. Included are suggestions for possible clinical validation studies.

Original language	English (US)
Pages (from-to)	77-92
Number of pages	16
Journal	Computational and Mathematical Methods in Medicine
Volume	8
Issue number	2
DOIs	https://doi.org/10.1080/17486700701349021
State	Published - Jun 2007
Externally published	Yes

Keywords

Benign prostate hyperplasia
Biomarker dynamics
Biomarker models
Prostate-specific antigen
Prostatic intraepithilial neoplasia

ASJC Scopus subject areas

Modeling and Simulation
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
Applied Mathematics

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10.1080/17486700701349021

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title = "Modeling biomarker dynamics with implications for the treatment of prostate cancer",

abstract = "The authors review existing models of biomarker dynamics and develop and investigate several new models which may better accommodate the underlying biology. While the general foundations of the models studied could be applied to a number of biomarker systems, the parameter values and specific applications to treatment regimens are focused on the role of prostate-specific antigen (PSA) as a biomarker for prostate cancer. Included are suggestions for possible clinical validation studies.",

keywords = "Benign prostate hyperplasia, Biomarker dynamics, Biomarker models, Prostate-specific antigen, Prostatic intraepithilial neoplasia",

author = "Hedican, {Erin B.} and Kemper, {John T.} and Lanie, {Nicole M.}",

year = "2007",

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AU - Kemper, John T.

AU - Lanie, Nicole M.

PY - 2007/6

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N2 - The authors review existing models of biomarker dynamics and develop and investigate several new models which may better accommodate the underlying biology. While the general foundations of the models studied could be applied to a number of biomarker systems, the parameter values and specific applications to treatment regimens are focused on the role of prostate-specific antigen (PSA) as a biomarker for prostate cancer. Included are suggestions for possible clinical validation studies.

AB - The authors review existing models of biomarker dynamics and develop and investigate several new models which may better accommodate the underlying biology. While the general foundations of the models studied could be applied to a number of biomarker systems, the parameter values and specific applications to treatment regimens are focused on the role of prostate-specific antigen (PSA) as a biomarker for prostate cancer. Included are suggestions for possible clinical validation studies.

KW - Benign prostate hyperplasia

KW - Biomarker dynamics

KW - Biomarker models

KW - Prostate-specific antigen

KW - Prostatic intraepithilial neoplasia

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Modeling biomarker dynamics with implications for the treatment of prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

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