Minimalist IR and fluorescence probes of protein function

Pallavi M. Gosavi, Ivan V. Korendovych

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Spectroscopic studies of small proteins and peptides, especially those requiring fine spatial and/or temporal resolution, demand synthetic probes that confer the minimal possible steric and functional change on the native properties. Here we review the recent progress in development of minimally disruptive probes for fluorescence and infrared spectroscopies, as well as the methods to efficiently incorporate them into proteins. Advances in spectroscopy on the one hand result in high specialization of synthetic probes for a particular purpose, but on the other hand allow for the same probes be used for different techniques to gather complementary biochemical information.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalCurrent Opinion in Chemical Biology
StatePublished - Oct 1 2016

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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