Microtubules, MAPs, and motor patterns

Kasimira T. Stanhope, Jennifer L. Ross

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Cells have an amazing ability to self-organize and rearrange their interiors. Such morphology changes are essential to cell development, division, and motility. The core of a cell's internal organization lies with the cytoskeleton made of both microtubule and actin filaments with their associated proteins and ATP-utilizing enzymes. Despite years of in vitro reconstitution experiments, we still do not fully understand how the cytoskeleton can self-organize. In an attempt to create a simple system of self-organization, we have used a simple filament-gliding assay to examine how kinesin-1-driven motion of microtubules can generate cell-like organization in the presence of excess filaments and antiparallel cross-linkers.

Original languageEnglish (US)
Pages (from-to)23-38
Number of pages16
JournalMethods in cell biology
Volume128
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Active matter
  • Kinesin-1
  • Microtubule-associate proteins
  • Motor proteins
  • Nonequilibrium
  • Pattern formation
  • Quantitative biology
  • Synthetic biophysics

ASJC Scopus subject areas

  • Cell Biology

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