Microsystem for Stem Cell-Based Cardiovascular Research

Huaxiao Yang, Zhen Ma

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


The emergence of microsystem offers a tool to analyze the biophysical and biochemical functions of individual cells for biosensing, disease diagnostics, drug screening, and fundamental research. With the rapid expansion and eager need for stem cell-based regenerative medicine, introducing microsystem to stem cell research allows locating, culturing, and reprogramming stem cells under a highly controlled microenvironment, including geometrical restriction, surface biochemistry, extracellular matrix (ECM) composites, and cell-cell interactions. This review focused on the application of microtechnology in stem cell-based cardiovascular research to discuss the creation of biomimetic cardiac microenvironment and its influence on stem cell cardiomyogenic differentiation and stem cell-cardiomyocyte interaction. This review was divided into four sections: three-dimensional tissue construction, two-dimensional cell alignment, single-cell micropatterning and analysis, and development of advanced microsystem "heart-on-a-chip".

Original languageEnglish (US)
Pages (from-to)305-315
Number of pages11
Issue number4
StatePublished - Nov 2012
Externally publishedYes


  • Cardiac tissue engineering
  • Cell patterning
  • Heart on a chip
  • Microsystem
  • Regenerative medicine
  • Stem cell biology

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering


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