Microcrystallography, high-pressure cryocooling and BioSAXS at MacCHESS

Ulrich Englich, Irina A. Kriksunov, Richard A. Cerione, Michael J. Cook, Richard Gillilan, Sol M. Gruner, Qingqui Huang, Chae Un Kim, William Miller, Soren Nielsen, David Schuller, Scott Smith, Doletha M.E. Szebenyi

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The Macromolecular Diffraction Facility at the Cornell High Energy Synchrotron Source (MacCHESS) is a national research resource supported by the National Center for Research Resources of the US National Institutes of Health. MacCHESS is pursuing several research initiatives designed to benefit both CHESS users and the wider structural biology community. Three initiatives are presented in further detail: microcrystallography, which aims to improve the collection of diffraction data from crystals a few micrometers across, or small well diffracting regions of inhomogeneous crystals, so as to obtain high-resolution structures; pressure cryocooling, which can stabilize transient structures and reduce lattice damage during the cooling process; and BioSAXS (small-angle X-ray scattering on biological solutions), which can extract molecular shape and other structural information from macromolecules in solution.

Original languageEnglish (US)
Pages (from-to)70-73
Number of pages4
JournalJournal of Synchrotron Radiation
Volume18
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • BioSAXS
  • cryo
  • microcrystallography
  • pressure
  • protein crystallography

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Instrumentation

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    Englich, U., Kriksunov, I. A., Cerione, R. A., Cook, M. J., Gillilan, R., Gruner, S. M., Huang, Q., Kim, C. U., Miller, W., Nielsen, S., Schuller, D., Smith, S., & Szebenyi, D. M. E. (2011). Microcrystallography, high-pressure cryocooling and BioSAXS at MacCHESS. Journal of Synchrotron Radiation, 18(1), 70-73. https://doi.org/10.1107/S0909049510036010