TY - JOUR
T1 - Micro-engineered architected metamaterials for cell and tissue engineering
AU - Wang, Chenyan
AU - Vangelatos, Zacharias
AU - Grigoropoulos, Costas P.
AU - Ma, Zhen
N1 - Funding Information:
This work was supported by NSF ( CBET-1804875 , CBET-1804922 , CBET-1943798 , CMMI-2130192 and SNM-1449305 ) and Syracuse University intramural CUSE Grant.
Publisher Copyright:
© 2022 The Authors
PY - 2022/3
Y1 - 2022/3
N2 - Architected metamaterials are built upon the assembly of repeating cellular structures, exhibiting unprecedented mechanical properties attributed to the tunability of cellular geometries. They have demonstrated a wide range of applications in the optical and electromagnetic fields, and recently they are employed as advanced tissue engineering scaffolds. The microgeometry-driven strategy enlarges the design domain of scaffold features and enables more accurate manipulation of cell-material interactions. In this review, we introduce the most popular metamaterial designs in biomedical engineering and summarize their representative applications to fabricate in vitro models and in vivo implants. These studies validate the unique advantages of metamaterials in supporting mechanobiological studies and improving the functionality of tissue replacements. Nevertheless, the evolution of meta-biomaterials requires more detailed investigations of the relationship between structural designs and cell phenotypes as well as accurate theoretical models.
AB - Architected metamaterials are built upon the assembly of repeating cellular structures, exhibiting unprecedented mechanical properties attributed to the tunability of cellular geometries. They have demonstrated a wide range of applications in the optical and electromagnetic fields, and recently they are employed as advanced tissue engineering scaffolds. The microgeometry-driven strategy enlarges the design domain of scaffold features and enables more accurate manipulation of cell-material interactions. In this review, we introduce the most popular metamaterial designs in biomedical engineering and summarize their representative applications to fabricate in vitro models and in vivo implants. These studies validate the unique advantages of metamaterials in supporting mechanobiological studies and improving the functionality of tissue replacements. Nevertheless, the evolution of meta-biomaterials requires more detailed investigations of the relationship between structural designs and cell phenotypes as well as accurate theoretical models.
KW - Biomaterials
KW - Mechanical metamaterials
KW - Meta-implants
KW - Tissue engineering
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U2 - 10.1016/j.mtadv.2022.100206
DO - 10.1016/j.mtadv.2022.100206
M3 - Article
AN - SCOPUS:85122615118
SN - 2590-0498
VL - 13
JO - Materials Today Advances
JF - Materials Today Advances
M1 - 100206
ER -