Micro-CT system for small animal imaging with ultrafast laser-based x-ray source

A. Krol, J. C. Kieffer, L. Chen, R. Toth, I. L. Coman, E. D. Lipson, R. E. Kincaid, Charles C. Chamberlain

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

A novel ultrafast-laser-based x-ray source is a promising candidate for replacement of a microfocal X-ray tube in a micro-CT system for small-animal imaging. We optimized conditions for x-ray generation from a very small (below 5 μm) focal spot. We measured x-ray spectra, conversion efficiency, x-ray fluence, and x-ray focal-spot size for a number of solid targets (SiO 2, Ge, Mo, Ag, Sn, BaF2, La, Nd, Gd, Ta, and Pb). X-ray spectra created by ultrafast laser are advantageous for micro-CT imaging, because most of the emission is in narrow characteristic lines. The spectra can be changed rapidly and matched to the imaging task. They make practical the use of dual-energy micro-CT with suitable contrast agents and matching targets and filters for low- and high-energy beams. We have obtained images of small animals in single- and dual-energy modes.

Original languageEnglish (US)
Title of host publication2004 2nd IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationMacro to Nano
Pages1516-1519
Number of pages4
StatePublished - Dec 1 2004
Event2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano - Arlington, VA, United States
Duration: Apr 15 2004Apr 18 2004

Publication series

Name2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
Volume2

Other

Other2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
CountryUnited States
CityArlington, VA
Period4/15/044/18/04

ASJC Scopus subject areas

  • Engineering(all)

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    Krol, A., Kieffer, J. C., Chen, L., Toth, R., Coman, I. L., Lipson, E. D., Kincaid, R. E., & Chamberlain, C. C. (2004). Micro-CT system for small animal imaging with ultrafast laser-based x-ray source. In 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano (pp. 1516-1519). (2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano; Vol. 2).