Micro-CT system for small animal imaging with ultrafast laser-based x-ray source

A. Krol; J. C. Kieffer; L. Chen; R. Toth; I. L. Coman; E. D. Lipson; R. E. Kincaid; Charles C. Chamberlain

Micro-CT system for small animal imaging with ultrafast laser-based x-ray source

A. Krol, J. C. Kieffer, L. Chen, R. Toth, I. L. Coman, E. D. Lipson, R. E. Kincaid, Charles C. Chamberlain

Department of Physics

Research output: Chapter in Book/Entry/Poem › Conference contribution

1 Scopus citations

Abstract

A novel ultrafast-laser-based x-ray source is a promising candidate for replacement of a microfocal X-ray tube in a micro-CT system for small-animal imaging. We optimized conditions for x-ray generation from a very small (below 5 μm) focal spot. We measured x-ray spectra, conversion efficiency, x-ray fluence, and x-ray focal-spot size for a number of solid targets (SiO ₂, Ge, Mo, Ag, Sn, BaF₂, La, Nd, Gd, Ta, and Pb). X-ray spectra created by ultrafast laser are advantageous for micro-CT imaging, because most of the emission is in narrow characteristic lines. The spectra can be changed rapidly and matched to the imaging task. They make practical the use of dual-energy micro-CT with suitable contrast agents and matching targets and filters for low- and high-energy beams. We have obtained images of small animals in single- and dual-energy modes.

Original language	English (US)
Title of host publication	2004 2nd IEEE International Symposium on Biomedical Imaging
Subtitle of host publication	Macro to Nano
Pages	1516-1519
Number of pages	4
State	Published - 2004
Event	2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano - Arlington, VA, United States Duration: Apr 15 2004 → Apr 18 2004

Publication series

Name	2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
Volume	2

Other

Other	2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
Country/Territory	United States
City	Arlington, VA
Period	4/15/04 → 4/18/04

ASJC Scopus subject areas

General Engineering

Cite this

Krol, A., Kieffer, J. C., Chen, L., Toth, R., Coman, I. L., Lipson, E. D., Kincaid, R. E., & Chamberlain, C. C. (2004). Micro-CT system for small animal imaging with ultrafast laser-based x-ray source. In 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano (pp. 1516-1519). (2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano; Vol. 2).

Micro-CT system for small animal imaging with ultrafast laser-based x-ray source. / Krol, A.; Kieffer, J. C.; Chen, L. et al.
2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano. 2004. p. 1516-1519 (2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano; Vol. 2).

Research output: Chapter in Book/Entry/Poem › Conference contribution

Krol, A, Kieffer, JC, Chen, L, Toth, R, Coman, IL, Lipson, ED, Kincaid, RE & Chamberlain, CC 2004, Micro-CT system for small animal imaging with ultrafast laser-based x-ray source. in 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano. 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano, vol. 2, pp. 1516-1519, 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano, Arlington, VA, United States, 4/15/04.

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title = "Micro-CT system for small animal imaging with ultrafast laser-based x-ray source",

abstract = "A novel ultrafast-laser-based x-ray source is a promising candidate for replacement of a microfocal X-ray tube in a micro-CT system for small-animal imaging. We optimized conditions for x-ray generation from a very small (below 5 μm) focal spot. We measured x-ray spectra, conversion efficiency, x-ray fluence, and x-ray focal-spot size for a number of solid targets (SiO 2, Ge, Mo, Ag, Sn, BaF2, La, Nd, Gd, Ta, and Pb). X-ray spectra created by ultrafast laser are advantageous for micro-CT imaging, because most of the emission is in narrow characteristic lines. The spectra can be changed rapidly and matched to the imaging task. They make practical the use of dual-energy micro-CT with suitable contrast agents and matching targets and filters for low- and high-energy beams. We have obtained images of small animals in single- and dual-energy modes.",

author = "A. Krol and Kieffer, {J. C.} and L. Chen and R. Toth and Coman, {I. L.} and Lipson, {E. D.} and Kincaid, {R. E.} and Chamberlain, {Charles C.}",

year = "2004",

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AU - Krol, A.

AU - Kieffer, J. C.

AU - Chen, L.

AU - Toth, R.

AU - Coman, I. L.

AU - Lipson, E. D.

AU - Kincaid, R. E.

AU - Chamberlain, Charles C.

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Y1 - 2004

N2 - A novel ultrafast-laser-based x-ray source is a promising candidate for replacement of a microfocal X-ray tube in a micro-CT system for small-animal imaging. We optimized conditions for x-ray generation from a very small (below 5 μm) focal spot. We measured x-ray spectra, conversion efficiency, x-ray fluence, and x-ray focal-spot size for a number of solid targets (SiO 2, Ge, Mo, Ag, Sn, BaF2, La, Nd, Gd, Ta, and Pb). X-ray spectra created by ultrafast laser are advantageous for micro-CT imaging, because most of the emission is in narrow characteristic lines. The spectra can be changed rapidly and matched to the imaging task. They make practical the use of dual-energy micro-CT with suitable contrast agents and matching targets and filters for low- and high-energy beams. We have obtained images of small animals in single- and dual-energy modes.

AB - A novel ultrafast-laser-based x-ray source is a promising candidate for replacement of a microfocal X-ray tube in a micro-CT system for small-animal imaging. We optimized conditions for x-ray generation from a very small (below 5 μm) focal spot. We measured x-ray spectra, conversion efficiency, x-ray fluence, and x-ray focal-spot size for a number of solid targets (SiO 2, Ge, Mo, Ag, Sn, BaF2, La, Nd, Gd, Ta, and Pb). X-ray spectra created by ultrafast laser are advantageous for micro-CT imaging, because most of the emission is in narrow characteristic lines. The spectra can be changed rapidly and matched to the imaging task. They make practical the use of dual-energy micro-CT with suitable contrast agents and matching targets and filters for low- and high-energy beams. We have obtained images of small animals in single- and dual-energy modes.

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M3 - Conference contribution

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BT - 2004 2nd IEEE International Symposium on Biomedical Imaging

T2 - 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano

Y2 - 15 April 2004 through 18 April 2004

ER -

Micro-CT system for small animal imaging with ultrafast laser-based x-ray source

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