Memory storage impairment or retrieval failure: Pharmacologically distinguishable processes

Thomas J. Walsh; Tibor Palfai

doi:10.1016/0091-3057(79)90124-2

Memory storage impairment or retrieval failure: Pharmacologically distinguishable processes

Thomas J. Walsh, Tibor Palfai

Department of Psychology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The effects of reserpine and syrosingopine on retention of a passive avoidance task in mice were investigated. Following repeated exposure to the training apparatus, the amnesia induced with syrosingopine could be reversed, the amnesia induced with reserpine could not. The amnesia produced by these agents was still evident 35 days following training. The results were discussed in terms of the effects of these drugs on memory consolidation and/or retrieval.

Original language	English (US)
Pages (from-to)	453-456
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	11
Issue number	4
DOIs	https://doi.org/10.1016/0091-3057(79)90124-2
State	Published - Oct 1979

Keywords

Amnesia
Consolidation
Memory
Rauwolfia alkaloids
Retrieval

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(79)90124-2

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title = "Memory storage impairment or retrieval failure: Pharmacologically distinguishable processes",

abstract = "The effects of reserpine and syrosingopine on retention of a passive avoidance task in mice were investigated. Following repeated exposure to the training apparatus, the amnesia induced with syrosingopine could be reversed, the amnesia induced with reserpine could not. The amnesia produced by these agents was still evident 35 days following training. The results were discussed in terms of the effects of these drugs on memory consolidation and/or retrieval.",

keywords = "Amnesia, Consolidation, Memory, Rauwolfia alkaloids, Retrieval",

author = "Walsh, {Thomas J.} and Tibor Palfai",

note = "Funding Information: A step-through passive avoidance apparatus, similar to that of Jarvik and Kopp \[9\]w as used. Briefly, the apparatus consisted of a V-shaped trough that was divided by a 'Supported by Syracuse University Institutional Grant. ~We would like to thank Ciba-Geigy for the generous gift of the syrosingopine.",

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T1 - Memory storage impairment or retrieval failure

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AU - Walsh, Thomas J.

AU - Palfai, Tibor

N1 - Funding Information: A step-through passive avoidance apparatus, similar to that of Jarvik and Kopp \[9\]w as used. Briefly, the apparatus consisted of a V-shaped trough that was divided by a 'Supported by Syracuse University Institutional Grant. ~We would like to thank Ciba-Geigy for the generous gift of the syrosingopine.

PY - 1979/10

Y1 - 1979/10

N2 - The effects of reserpine and syrosingopine on retention of a passive avoidance task in mice were investigated. Following repeated exposure to the training apparatus, the amnesia induced with syrosingopine could be reversed, the amnesia induced with reserpine could not. The amnesia produced by these agents was still evident 35 days following training. The results were discussed in terms of the effects of these drugs on memory consolidation and/or retrieval.

AB - The effects of reserpine and syrosingopine on retention of a passive avoidance task in mice were investigated. Following repeated exposure to the training apparatus, the amnesia induced with syrosingopine could be reversed, the amnesia induced with reserpine could not. The amnesia produced by these agents was still evident 35 days following training. The results were discussed in terms of the effects of these drugs on memory consolidation and/or retrieval.

KW - Amnesia

KW - Consolidation

KW - Memory

KW - Rauwolfia alkaloids

KW - Retrieval

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JO - Pharmacology Biochemistry and Behavior

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Memory storage impairment or retrieval failure: Pharmacologically distinguishable processes

Abstract

Keywords

ASJC Scopus subject areas

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