Memory scores in middle-aged rats predict later deficits in memory, paradoxical sleep, and blood glucose regulation in old age

W. S. Stone, R. J. Rudd, M. W. Parsons, P. E. Gold

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Age-related deficits in memory are correlated with deficits in paradoxical sleep and poor glucose tolerance in rats. The present experiment used a longitudinal design to determine whether memory or glucose tolerance in middle-aged rats could predict deficits in memory, sleep, and glucose tolerance in old age. Correlations were obtained between spontaneous alternation scores and glucose tolerance levels in middle age (14 months) and inhibitory avoidance, daytime sleep, and glucose tolerance levels in old age (24 months). Spontaneous alternation scores, but not glucose tolerance levels, predicted performance on all 3 behavioral and biological measures in old age. Measures of functional integrity, such as memory, may be sensitive predictors of subsequent age-related change in specific cognitive and neurobiological sy stems.

Original languageEnglish (US)
Pages (from-to)287-300
Number of pages14
JournalExperimental Aging Research
Volume23
Issue number3
DOIs
StatePublished - Jul 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Aging
  • Arts and Humanities (miscellaneous)
  • Psychology(all)
  • Geriatrics and Gerontology

Fingerprint Dive into the research topics of 'Memory scores in middle-aged rats predict later deficits in memory, paradoxical sleep, and blood glucose regulation in old age'. Together they form a unique fingerprint.

  • Cite this