Memory facilitation and impairment with supraseizure electrical brain stimulation: attenuation with pretrial propranolol injections

Debra B. Sternberg; Paul E. Gold; James L. McGaugh

doi:10.1016/S0163-1047(83)90268-6

Memory facilitation and impairment with supraseizure electrical brain stimulation: attenuation with pretrial propranolol injections

Debra B. Sternberg, Paul E. Gold, James L. McGaugh

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Post-training supraseizure stimulation of frontal cortex enhances retention of active avoidance in rats trained using a low footshock but impairs retention when high footshock is used in training. Pretreatment with the adrenergic antagonist propranolol results in attenuation of both memory facilitation and amnesia. These results are consistent with previous evidence indicating that adrenergic antagonists attenuate amnesia and facilitation produced by a variety of agents and suggest that memory modulatory treatments may enhance or impair memory by actions which include effects on adrenergic systems.

Original language	English (US)
Pages (from-to)	261-268
Number of pages	8
Journal	Behavioral and Neural Biology
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/S0163-1047(83)90268-6
State	Published - Jul 1983
Externally published	Yes

ASJC Scopus subject areas

Physiology

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10.1016/S0163-1047(83)90268-6

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title = "Memory facilitation and impairment with supraseizure electrical brain stimulation: attenuation with pretrial propranolol injections",

abstract = "Post-training supraseizure stimulation of frontal cortex enhances retention of active avoidance in rats trained using a low footshock but impairs retention when high footshock is used in training. Pretreatment with the adrenergic antagonist propranolol results in attenuation of both memory facilitation and amnesia. These results are consistent with previous evidence indicating that adrenergic antagonists attenuate amnesia and facilitation produced by a variety of agents and suggest that memory modulatory treatments may enhance or impair memory by actions which include effects on adrenergic systems.",

author = "Sternberg, {Debra B.} and Gold, {Paul E.} and McGaugh, {James L.}",

note = "Funding Information: 2 This research was supported by USPHS Postdoctoral Fellowship MH 08646 (to D.B.S.), Research Grants MH 31141 and AG 01642 (to P.E.G.), and MH 12526 and AG 00538 (to J.L.McG.). Send requests for reprints to Dr. Debra B. Sternberg.",

year = "1983",

month = jul,

doi = "10.1016/S0163-1047(83)90268-6",

language = "English (US)",

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journal = "Behavioral and Neural Biology",

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T1 - Memory facilitation and impairment with supraseizure electrical brain stimulation

T2 - attenuation with pretrial propranolol injections

AU - Sternberg, Debra B.

AU - Gold, Paul E.

AU - McGaugh, James L.

N1 - Funding Information: 2 This research was supported by USPHS Postdoctoral Fellowship MH 08646 (to D.B.S.), Research Grants MH 31141 and AG 01642 (to P.E.G.), and MH 12526 and AG 00538 (to J.L.McG.). Send requests for reprints to Dr. Debra B. Sternberg.

PY - 1983/7

Y1 - 1983/7

N2 - Post-training supraseizure stimulation of frontal cortex enhances retention of active avoidance in rats trained using a low footshock but impairs retention when high footshock is used in training. Pretreatment with the adrenergic antagonist propranolol results in attenuation of both memory facilitation and amnesia. These results are consistent with previous evidence indicating that adrenergic antagonists attenuate amnesia and facilitation produced by a variety of agents and suggest that memory modulatory treatments may enhance or impair memory by actions which include effects on adrenergic systems.

AB - Post-training supraseizure stimulation of frontal cortex enhances retention of active avoidance in rats trained using a low footshock but impairs retention when high footshock is used in training. Pretreatment with the adrenergic antagonist propranolol results in attenuation of both memory facilitation and amnesia. These results are consistent with previous evidence indicating that adrenergic antagonists attenuate amnesia and facilitation produced by a variety of agents and suggest that memory modulatory treatments may enhance or impair memory by actions which include effects on adrenergic systems.

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Memory facilitation and impairment with supraseizure electrical brain stimulation: attenuation with pretrial propranolol injections

Abstract

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