Meiotic silencing in Caenorhabditis elegans

Research output: Book/ReportBook

16 Citations (Scopus)

Abstract

In many animals and some fungi, mechanisms have been described that target unpaired chromosomes and chromosomal regions for silencing during meiotic prophase. These phenomena, collectively called "meiotic silencing," target sex chromosomes in the heterogametic sex, for example, the X chromosome in male nematodes and the XY-body in male mice, and also target any other chromosomes that fail to synapse due to mutation or chromosomal rearrangement. Meiotic silencing phenomena are hypothesized to maintain genome integrity and perhaps function in setting up epigenetic control of embryogenesis. This review focuses on meiotic silencing in the nematode, Caenorhabditis elegans, including its mechanism and function(s), and its relationship to other gene silencing processes in the germ line. One hallmark of meiotic silencing in C. elegans is that unpaired/unsynapsed chromosomes and chromosomal regions become enriched for a repressive histone modification, dimethylation of histone H3 on lysine 9 (H3K9me2). Accumulation and proper targeting of H3K9me2 rely on activity of an siRNA pathway, suggesting that histone methyltransferase activity may be targeted/regulated by a small RNA-based transcriptional silencing mechanism.

Original languageEnglish (US)
PublisherUnknown Publisher
Number of pages44
Volume282
EditionC
DOIs
StatePublished - 2010

Publication series

NameInternational Review of Cell and Molecular Biology
No.C
Volume282
ISSN (Print)19376448

Fingerprint

Caenorhabditis elegans
Chromosomes
Histone Code
Histones
Prophase
Sex Chromosomes
Genes
X Chromosome
Gene Silencing
Epigenomics
Germ Cells
Synapses
Small Interfering RNA
Lysine
Embryonic Development
Fungi
Genome
RNA
Mutation
Animals

Keywords

  • Chromatin
  • Germ line
  • H3K9me2
  • Histone modification
  • Meiotic silencing
  • RNA-directed RNA polymerase
  • RNAi
  • X chromosome

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Maine, E. M. (2010). Meiotic silencing in Caenorhabditis elegans. (C ed.) (International Review of Cell and Molecular Biology; Vol. 282, No. C). Unknown Publisher. https://doi.org/10.1016/S1937-6448(10)82002-7

Meiotic silencing in Caenorhabditis elegans. / Maine, Eleanor M.

C ed. Unknown Publisher, 2010. 44 p. (International Review of Cell and Molecular Biology; Vol. 282, No. C).

Research output: Book/ReportBook

Maine, EM 2010, Meiotic silencing in Caenorhabditis elegans. International Review of Cell and Molecular Biology, no. C, vol. 282, vol. 282, C edn, Unknown Publisher. https://doi.org/10.1016/S1937-6448(10)82002-7
Maine EM. Meiotic silencing in Caenorhabditis elegans. C ed. Unknown Publisher, 2010. 44 p. (International Review of Cell and Molecular Biology; C). https://doi.org/10.1016/S1937-6448(10)82002-7
Maine, Eleanor M. / Meiotic silencing in Caenorhabditis elegans. C ed. Unknown Publisher, 2010. 44 p. (International Review of Cell and Molecular Biology; C).
@book{4b38fcf06953473fa9fa80a2552a26a7,
title = "Meiotic silencing in Caenorhabditis elegans",
abstract = "In many animals and some fungi, mechanisms have been described that target unpaired chromosomes and chromosomal regions for silencing during meiotic prophase. These phenomena, collectively called {"}meiotic silencing,{"} target sex chromosomes in the heterogametic sex, for example, the X chromosome in male nematodes and the XY-body in male mice, and also target any other chromosomes that fail to synapse due to mutation or chromosomal rearrangement. Meiotic silencing phenomena are hypothesized to maintain genome integrity and perhaps function in setting up epigenetic control of embryogenesis. This review focuses on meiotic silencing in the nematode, Caenorhabditis elegans, including its mechanism and function(s), and its relationship to other gene silencing processes in the germ line. One hallmark of meiotic silencing in C. elegans is that unpaired/unsynapsed chromosomes and chromosomal regions become enriched for a repressive histone modification, dimethylation of histone H3 on lysine 9 (H3K9me2). Accumulation and proper targeting of H3K9me2 rely on activity of an siRNA pathway, suggesting that histone methyltransferase activity may be targeted/regulated by a small RNA-based transcriptional silencing mechanism.",
keywords = "Chromatin, Germ line, H3K9me2, Histone modification, Meiotic silencing, RNA-directed RNA polymerase, RNAi, X chromosome",
author = "Maine, {Eleanor M}",
year = "2010",
doi = "10.1016/S1937-6448(10)82002-7",
language = "English (US)",
volume = "282",
series = "International Review of Cell and Molecular Biology",
publisher = "Unknown Publisher",
number = "C",
edition = "C",

}

TY - BOOK

T1 - Meiotic silencing in Caenorhabditis elegans

AU - Maine, Eleanor M

PY - 2010

Y1 - 2010

N2 - In many animals and some fungi, mechanisms have been described that target unpaired chromosomes and chromosomal regions for silencing during meiotic prophase. These phenomena, collectively called "meiotic silencing," target sex chromosomes in the heterogametic sex, for example, the X chromosome in male nematodes and the XY-body in male mice, and also target any other chromosomes that fail to synapse due to mutation or chromosomal rearrangement. Meiotic silencing phenomena are hypothesized to maintain genome integrity and perhaps function in setting up epigenetic control of embryogenesis. This review focuses on meiotic silencing in the nematode, Caenorhabditis elegans, including its mechanism and function(s), and its relationship to other gene silencing processes in the germ line. One hallmark of meiotic silencing in C. elegans is that unpaired/unsynapsed chromosomes and chromosomal regions become enriched for a repressive histone modification, dimethylation of histone H3 on lysine 9 (H3K9me2). Accumulation and proper targeting of H3K9me2 rely on activity of an siRNA pathway, suggesting that histone methyltransferase activity may be targeted/regulated by a small RNA-based transcriptional silencing mechanism.

AB - In many animals and some fungi, mechanisms have been described that target unpaired chromosomes and chromosomal regions for silencing during meiotic prophase. These phenomena, collectively called "meiotic silencing," target sex chromosomes in the heterogametic sex, for example, the X chromosome in male nematodes and the XY-body in male mice, and also target any other chromosomes that fail to synapse due to mutation or chromosomal rearrangement. Meiotic silencing phenomena are hypothesized to maintain genome integrity and perhaps function in setting up epigenetic control of embryogenesis. This review focuses on meiotic silencing in the nematode, Caenorhabditis elegans, including its mechanism and function(s), and its relationship to other gene silencing processes in the germ line. One hallmark of meiotic silencing in C. elegans is that unpaired/unsynapsed chromosomes and chromosomal regions become enriched for a repressive histone modification, dimethylation of histone H3 on lysine 9 (H3K9me2). Accumulation and proper targeting of H3K9me2 rely on activity of an siRNA pathway, suggesting that histone methyltransferase activity may be targeted/regulated by a small RNA-based transcriptional silencing mechanism.

KW - Chromatin

KW - Germ line

KW - H3K9me2

KW - Histone modification

KW - Meiotic silencing

KW - RNA-directed RNA polymerase

KW - RNAi

KW - X chromosome

UR - http://www.scopus.com/inward/record.url?scp=77957928823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957928823&partnerID=8YFLogxK

U2 - 10.1016/S1937-6448(10)82002-7

DO - 10.1016/S1937-6448(10)82002-7

M3 - Book

VL - 282

T3 - International Review of Cell and Molecular Biology

BT - Meiotic silencing in Caenorhabditis elegans

PB - Unknown Publisher

ER -