TY - JOUR
T1 - Mechanisms of ventral patterning in the vertebrate nervous system
AU - Lupo, Giuseppe
AU - Harris, William A.
AU - Lewis, Katharine E.
N1 - Funding Information:
We thank the referees for helpful comments on earlier drafts of this manuscript and we apologise to any of our colleagues whose work we have failed to cite due to space limitations. Work in K.E.L.’s laboratory is funded by the Royal Society, London, UK, and Cambridge University Isaac Newton Trust, UK; work in W.A.H.’s laboratory is funded by the Wellcome Trust, London, UK.
PY - 2006/2
Y1 - 2006/2
N2 - Dorsoventral patterning of the neural tube has a crucial role in shaping the functional organization of the CNS. It is well established that hedgehog signalling plays a key role in specifying ventral cell types throughout the neuroectoderm, and major progress has been made in elucidating how hedgehog signalling works in this ventral specification. In addition, other molecular pathways, including nodal, retinoic acid and fibroblast growth factor signalling, have been identified as important molecular cues for ventral patterning of the spinal cord, telencephalon and eye. Here, we discuss recent advances in this field, highlighting the emerging interplay of these signalling pathways in the molecular specification of ventral patterning at different rostrocaudal levels of the CNS.
AB - Dorsoventral patterning of the neural tube has a crucial role in shaping the functional organization of the CNS. It is well established that hedgehog signalling plays a key role in specifying ventral cell types throughout the neuroectoderm, and major progress has been made in elucidating how hedgehog signalling works in this ventral specification. In addition, other molecular pathways, including nodal, retinoic acid and fibroblast growth factor signalling, have been identified as important molecular cues for ventral patterning of the spinal cord, telencephalon and eye. Here, we discuss recent advances in this field, highlighting the emerging interplay of these signalling pathways in the molecular specification of ventral patterning at different rostrocaudal levels of the CNS.
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U2 - 10.1038/nrn1843
DO - 10.1038/nrn1843
M3 - Review article
C2 - 16429120
AN - SCOPUS:31444436983
SN - 1471-003X
VL - 7
SP - 103
EP - 114
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 2
ER -