Mechanisms of ventral patterning in the vertebrate nervous system

Giuseppe Lupo, William A. Harris, Katharine E. Lewis

Research output: Contribution to journalReview articlepeer-review

170 Scopus citations


Dorsoventral patterning of the neural tube has a crucial role in shaping the functional organization of the CNS. It is well established that hedgehog signalling plays a key role in specifying ventral cell types throughout the neuroectoderm, and major progress has been made in elucidating how hedgehog signalling works in this ventral specification. In addition, other molecular pathways, including nodal, retinoic acid and fibroblast growth factor signalling, have been identified as important molecular cues for ventral patterning of the spinal cord, telencephalon and eye. Here, we discuss recent advances in this field, highlighting the emerging interplay of these signalling pathways in the molecular specification of ventral patterning at different rostrocaudal levels of the CNS.

Original languageEnglish (US)
Pages (from-to)103-114
Number of pages12
JournalNature Reviews Neuroscience
Issue number2
StatePublished - Feb 2006
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Mechanisms of ventral patterning in the vertebrate nervous system'. Together they form a unique fingerprint.

Cite this