Mechanisms of the antioxidant effects of nitric oxide

David A. Wink, Katrina M. Miranda, Michael G. Espey, Ryzard M. Pluta, Sandra J. Hewett, Carol Colton, Michael Vitek, Martin Feelisch, Mathew B. Grisham

Research output: Contribution to journalReview article

241 Scopus citations

Abstract

The Janus face of nitric oxide (NO) has prompted a debate as to whether NO plays a deleterious or protective role in tissue injury. There are a number of reactive nitrogen oxide species, such as N2O3 and ONOO-, that can alter critical cellular components under high local concentrations of NO. However, NO can also abate the oxidation chemistry mediated by reactive oxygen species such as H2O2 and O2- that occurs at physiological levels of NO. In addition to the antioxidant chemistry, NO protects against cell death mediated by H2O2, alkylhydroperoxides, and xanthine oxidase. The attenuation of metal/peroxide oxidative chemistry, as well as lipid peroxidation, appears to be the major chemical mechanisms by which NO may limit oxidative injury to mammalian cells. In addition to these chemical and biochemical properties, NO can modulate cellular and physiological processes to limit oxidative injury, limiting processes such as leukocyte adhesion. This review will address these aspects of the chemical biology of this multifaceted free radical and explore the beneficial effect of NO against oxidative stress.

Original languageEnglish (US)
Pages (from-to)203-213
Number of pages11
JournalAntioxidants and Redox Signaling
Volume3
Issue number2
DOIs
StatePublished - Apr 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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    Wink, D. A., Miranda, K. M., Espey, M. G., Pluta, R. M., Hewett, S. J., Colton, C., Vitek, M., Feelisch, M., & Grisham, M. B. (2001). Mechanisms of the antioxidant effects of nitric oxide. Antioxidants and Redox Signaling, 3(2), 203-213. https://doi.org/10.1089/152308601300185179