Measuring protein elasticity with terahertz spectroscopy

Michael T. Ruggiero, Timothy Michael Korter

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Elasticity is a key parameter in evaluating the structural stability of large polymeric molecules such as polysaccharides and polypeptides. The determination of the elastic parameters of complex biomolecules has been a long-standing challenge and terahertz spectroscopy is emerging as an ideal approach for such measurements. A new methodology is presented here, combining time-domain terahertz spectroscopy, X-ray diffraction, and solid-state density functional theory to achieve high-accuracy values for the Young's moduli of biopolymers. The capabilities are demonstrated by application of this method to crystalline poly-L-proline helices and other polypeptides.

Original languageEnglish (US)
Title of host publication41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016
PublisherIEEE Computer Society
Volume2016-November
ISBN (Electronic)9781467384858
DOIs
StatePublished - Nov 28 2016
Event41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016 - Copenhagen, Denmark
Duration: Sep 25 2016Sep 30 2016

Other

Other41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016
CountryDenmark
CityCopenhagen
Period9/25/169/30/16

Fingerprint

Terahertz spectroscopy
Polypeptides
Elasticity
Proteins
Biopolymers
Biomolecules
Polysaccharides
Density functional theory
Elastic moduli
Crystalline materials
X ray diffraction
Molecules

ASJC Scopus subject areas

  • Energy Engineering and Power Technology
  • Electrical and Electronic Engineering

Cite this

Ruggiero, M. T., & Korter, T. M. (2016). Measuring protein elasticity with terahertz spectroscopy. In 41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016 (Vol. 2016-November). [7758346] IEEE Computer Society. https://doi.org/10.1109/IRMMW-THz.2016.7758346

Measuring protein elasticity with terahertz spectroscopy. / Ruggiero, Michael T.; Korter, Timothy Michael.

41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016. Vol. 2016-November IEEE Computer Society, 2016. 7758346.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ruggiero, MT & Korter, TM 2016, Measuring protein elasticity with terahertz spectroscopy. in 41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016. vol. 2016-November, 7758346, IEEE Computer Society, 41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016, Copenhagen, Denmark, 9/25/16. https://doi.org/10.1109/IRMMW-THz.2016.7758346
Ruggiero MT, Korter TM. Measuring protein elasticity with terahertz spectroscopy. In 41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016. Vol. 2016-November. IEEE Computer Society. 2016. 7758346 https://doi.org/10.1109/IRMMW-THz.2016.7758346
Ruggiero, Michael T. ; Korter, Timothy Michael. / Measuring protein elasticity with terahertz spectroscopy. 41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016. Vol. 2016-November IEEE Computer Society, 2016.
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