Measuring protein elasticity with terahertz spectroscopy

Michael T. Ruggiero, Timothy Michael Korter

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Elasticity is a key parameter in evaluating the structural stability of large polymeric molecules such as polysaccharides and polypeptides. The determination of the elastic parameters of complex biomolecules has been a long-standing challenge and terahertz spectroscopy is emerging as an ideal approach for such measurements. A new methodology is presented here, combining time-domain terahertz spectroscopy, X-ray diffraction, and solid-state density functional theory to achieve high-accuracy values for the Young's moduli of biopolymers. The capabilities are demonstrated by application of this method to crystalline poly-L-proline helices and other polypeptides.

Original languageEnglish (US)
Title of host publication41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016
PublisherIEEE Computer Society
Volume2016-November
ISBN (Electronic)9781467384858
DOIs
StatePublished - Nov 28 2016
Event41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016 - Copenhagen, Denmark
Duration: Sep 25 2016Sep 30 2016

Other

Other41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016
CountryDenmark
CityCopenhagen
Period9/25/169/30/16

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ASJC Scopus subject areas

  • Energy Engineering and Power Technology
  • Electrical and Electronic Engineering

Cite this

Ruggiero, M. T., & Korter, T. M. (2016). Measuring protein elasticity with terahertz spectroscopy. In 41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016 (Vol. 2016-November). [7758346] IEEE Computer Society. https://doi.org/10.1109/IRMMW-THz.2016.7758346