Mean absorbed dose to mouse in micro-CT imaging with an ultrafast laser-based x-ray source

Andrzej Krol, Ye Hongwei, Russell Kincaid, John Boone, Marina Servol, Jean Claude Kieffer, Yakov Nesterets, Tim Gureyev, Andrew Stevenson, Steve Wilkins, Edward Lipson, Remy Toth, Andrew Pogany, Ioana Coman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

We have investigated theoretically the mean absorbed dose to the mouse in our newly constructed, in-line holography, x-ray phase-contrast, in-vivo, micro-CT system with an ultrafast laser-based x-ray (ULX) source. We assumed that the effective mouse diameter was 30 mm and the x-ray detector required minimum 30 μGy per frame to produce high quality images. The following laser target-filter combinations were considered: Ag-Ag, Mo-Mo, Sn-Sn. In addition, we considered narrow-pass multilayer x-ray mirrors. The corresponding ULX spectra were obtained using a CZT solid-state spectrometer. The approach used for dose computation was similar to human dose estimation. The mouse was modeled as a tissue-equivalent cylinder located at the isocenter with diameter 30 mm and density 1g/cm 3. A layer of dermis (skin and fur) with 1 mm thickness was also modeled. Imparted energy per volume was estimated for 1 keV wide x-ray energy intervals in the 6-100 keV range. Monte Carlo simulations were performed using the SIERRA code previously validated using 30 mm diameter PMMA phantom. The results obtained indicate that: a) the mean absorbed dose for ULX is less than or equal to that from a W-anode micro-CT tube operating at 30-40 kVp with 0.5 or 1.0 mm Al; b) for filter thickness above 100 μm, Sn-Sn results in the highest dose, followed by Ag-Ag and Mo-Mo; c) the multilayer x-ray mirror with FWHM ≤ 10 keV produces significantly lower dose than metallic foil filters. We conclude that ULX can provide better dose utilization than a microfocal x-ray tube for in vivo microtomography applications.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2007
Subtitle of host publicationPhysics of Medical Imaging
EditionPART 2
DOIs
StatePublished - Oct 15 2007
EventMedical Imaging 2007: Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 18 2007Feb 22 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
NumberPART 2
Volume6510
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2007: Physics of Medical Imaging
CountryUnited States
CitySan Diego, CA
Period2/18/072/22/07

Keywords

  • Micro-computed tomography
  • Monte Carlo simulation
  • Mouse imaging
  • Small animal x-ray dose
  • Ultrafast laser-based x-ray source

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Krol, A., Hongwei, Y., Kincaid, R., Boone, J., Servol, M., Kieffer, J. C., Nesterets, Y., Gureyev, T., Stevenson, A., Wilkins, S., Lipson, E., Toth, R., Pogany, A., & Coman, I. (2007). Mean absorbed dose to mouse in micro-CT imaging with an ultrafast laser-based x-ray source. In Medical Imaging 2007: Physics of Medical Imaging (PART 2 ed.). [65103P] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6510, No. PART 2). https://doi.org/10.1117/12.713827