Maternal obesity and its epigenetic effects

Latha Ramalingam; Nishan Sudheera Kalupahana; Kalhara R. Menikdiwela; Chathura Ratnayake; Naïma Moustaïd-Moussa

doi:10.1007/978-3-031-15485-0_31

Maternal obesity and its epigenetic effects

Latha Ramalingam, Nishan Sudheera Kalupahana, Kalhara R. Menikdiwela, Chathura Ratnayake, Naïma Moustaïd-Moussa

Department of Nutrition and Food Studies

Research output: Chapter in Book/Entry/Poem › Chapter

Abstract

Obesity is a growing epidemic in the United States and around the world. Along with it, childhood obesity is rising at alarming rates. Heritability of obesity is very high, and it afflicts more than 50% of women of reproductive age. Maternal obesity is associated with complications to the pregnant mom as well as the offspring. Maternal diets contribute to alterations in epigenetic profiles in the fetus which in turn contributes to abnormities in the offspring affecting various metabolic tissues in the offspring. This chapter will review maternal obesity, epigenetic modifications which include DNA methylation, histone modifications and microRNAs (miRNAs) and their alterations by overnutrition and physical activity. Furthermore, we will discuss research findings related to maternal obesity in human subjects and animal models, and its impact on the health of offspring.

Original language	English (US)
Title of host publication	The Active Female
Subtitle of host publication	Health Issues throughout the Lifespan
Publisher	Springer International Publishing
Pages	563-578
Number of pages	16
ISBN (Electronic)	9783031154850
ISBN (Print)	9783031154843
DOIs	https://doi.org/10.1007/978-3-031-15485-0_31
State	Published - Feb 27 2023

Keywords

Animal models
DNA methylation
Epigenetics
Histone modifications
Human studies
Maternal obesity
MicroRNA

ASJC Scopus subject areas

Medicine(all)
Social Sciences(all)

Access to Document

10.1007/978-3-031-15485-0_31

Cite this

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Maternal obesity and its epigenetic effects

Abstract

Keywords

ASJC Scopus subject areas

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