Major depression associated with earlier alcohol relapse in treated teens with AUD

Jack R. Cornelius; Stephen A. Maisto; Christopher S. Martin; Oscar G. Bukstein; Ihsan M. Salloum; Dennis C. Daley; D. Scott Wood; Duncan B. Clark

doi:10.1016/j.addbeh.2004.02.056

Major depression associated with earlier alcohol relapse in treated teens with AUD

Jack R. Cornelius, Stephen A. Maisto, Christopher S. Martin, Oscar G. Bukstein, Ihsan M. Salloum, Dennis C. Daley, D. Scott Wood, Duncan B. Clark

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

This study evaluated whether the common comorbid diagnosis of major depressive disorder (MDD) is associated with an earlier relapse to alcohol use among adolescents with an alcohol use disorder (AUD). The study sample consisted of 116 adolescents between the ages of 14 and 18 with an AUD recruited from treatment facilities in the Pittsburgh area, 50 of whom demonstrated a current MDD. An extensive baseline interview was conducted, followed by monthly interviews of alcohol use conducted by telephone for the following year. Those with current comorbid MDD demonstrated a median survival time of only 19 days until the first drink, while those without MDD demonstrated a median survival time of 45 days, which was a significant difference (Kaplan-Meier survival analysis, Breslow Test Statistic=4.27, df=1, P=.039). These results suggest that the comorbid presence of MDD is associated with an earlier relapse to alcohol use among adolescents with an AUD.

Original language	English (US)
Pages (from-to)	1035-1038
Number of pages	4
Journal	Addictive Behaviors
Volume	29
Issue number	5
DOIs	https://doi.org/10.1016/j.addbeh.2004.02.056
State	Published - Jul 2004
Externally published	Yes

Keywords

Adolescence
Alcohol use disorder
Comorbidity
Major depression
Relapse

ASJC Scopus subject areas

Medicine (miscellaneous)
Clinical Psychology
Toxicology
Psychiatry and Mental health

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10.1016/j.addbeh.2004.02.056

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title = "Major depression associated with earlier alcohol relapse in treated teens with AUD",

abstract = "This study evaluated whether the common comorbid diagnosis of major depressive disorder (MDD) is associated with an earlier relapse to alcohol use among adolescents with an alcohol use disorder (AUD). The study sample consisted of 116 adolescents between the ages of 14 and 18 with an AUD recruited from treatment facilities in the Pittsburgh area, 50 of whom demonstrated a current MDD. An extensive baseline interview was conducted, followed by monthly interviews of alcohol use conducted by telephone for the following year. Those with current comorbid MDD demonstrated a median survival time of only 19 days until the first drink, while those without MDD demonstrated a median survival time of 45 days, which was a significant difference (Kaplan-Meier survival analysis, Breslow Test Statistic=4.27, df=1, P=.039). These results suggest that the comorbid presence of MDD is associated with an earlier relapse to alcohol use among adolescents with an AUD.",

keywords = "Adolescence, Alcohol use disorder, Comorbidity, Major depression, Relapse",

author = "Cornelius, {Jack R.} and Maisto, {Stephen A.} and Martin, {Christopher S.} and Bukstein, {Oscar G.} and Salloum, {Ihsan M.} and Daley, {Dennis C.} and Wood, {D. Scott} and Clark, {Duncan B.}",

note = "Funding Information: This work was conducted at the Pittsburgh Adolescent Alcohol Research Center (PAARC), a center grant funded by the National Institute on Alcohol Abuse and Alcoholism (P50 AA08746). Additional funding was provided by the following grants: R01 AA013370, R01 DA14635, R01 AA13397, R01 AA11929, P50 DA05605, K01 AA00324, K02 AA0291, K02 AA00249, and a grant from the Department of Veterans Affairs (MIRECC to VISN 4, Stars and Stripes Network). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2004",

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doi = "10.1016/j.addbeh.2004.02.056",

language = "English (US)",

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AU - Maisto, Stephen A.

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AU - Bukstein, Oscar G.

AU - Salloum, Ihsan M.

AU - Daley, Dennis C.

AU - Wood, D. Scott

AU - Clark, Duncan B.

N1 - Funding Information: This work was conducted at the Pittsburgh Adolescent Alcohol Research Center (PAARC), a center grant funded by the National Institute on Alcohol Abuse and Alcoholism (P50 AA08746). Additional funding was provided by the following grants: R01 AA013370, R01 DA14635, R01 AA13397, R01 AA11929, P50 DA05605, K01 AA00324, K02 AA0291, K02 AA00249, and a grant from the Department of Veterans Affairs (MIRECC to VISN 4, Stars and Stripes Network). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2004/7

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N2 - This study evaluated whether the common comorbid diagnosis of major depressive disorder (MDD) is associated with an earlier relapse to alcohol use among adolescents with an alcohol use disorder (AUD). The study sample consisted of 116 adolescents between the ages of 14 and 18 with an AUD recruited from treatment facilities in the Pittsburgh area, 50 of whom demonstrated a current MDD. An extensive baseline interview was conducted, followed by monthly interviews of alcohol use conducted by telephone for the following year. Those with current comorbid MDD demonstrated a median survival time of only 19 days until the first drink, while those without MDD demonstrated a median survival time of 45 days, which was a significant difference (Kaplan-Meier survival analysis, Breslow Test Statistic=4.27, df=1, P=.039). These results suggest that the comorbid presence of MDD is associated with an earlier relapse to alcohol use among adolescents with an AUD.

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Major depression associated with earlier alcohol relapse in treated teens with AUD

Abstract

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