Low-level Pb and cardiovascular responses to acute stress in children: The role of cardiac autonomic regulation

Brooks B Gump, James A. MacKenzie, Kestutis Bendinskas, Robert Morgan, Amy K. Dumas, Christopher D. Palmer, Patrick J. Parsons

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: A number of studies suggest that Pb exposure increases cardiovascular disease risk in humans. As a potential mechanism for this effect, we recently reported a significant association between early childhood Pb levels and cardiovascular response to acute stress. The current study considers the association between current Pb levels and the autonomic nervous system activation pattern underlying the cardiovascular response to stress in a new cohort of children. Methods: We assessed blood Pb levels as well as cardiovascular responses to acute stress in 9-11. year old children (N = 140). Sympathetic activation (measured with pre-ejection period) and parasympathetic activation (measured with high frequency heart rate variability) were also assessed. Results: In a sample with very low levels of blood Pb (M = 1.01 μg/dL), we found that increasing blood Pb was associated with coinhibition of sympathetic and parasympathetic activation in response to acute stress. In addition, increasing Pb levels were associated with the hemodynamic stress response pattern typical of coinhibition - significantly greater vascular resistance and reduced stroke volume and cardiac output. Conclusions: Blood Pb levels were associated with significant autonomic and cardiovascular dysregulation in response to acute psychological stress in children. Moreover, these effects were significant at Pb levels considered to be very low and notably well below the 10 μg/dL, the Centers for Disease Control and Prevention definition of an elevated blood Pb level. The potential for autonomic dysregulation at levels of Pb typical for many US children would suggest potentially broad public health ramifications.

Original languageEnglish (US)
Pages (from-to)212-219
Number of pages8
JournalNeurotoxicology and Teratology
Volume33
Issue number2
DOIs
StatePublished - Mar 2011

Fingerprint

Blood
Chemical activation
Association reactions
Disease control
Autonomic Nervous System
Hemodynamics
Neurology
Public health
Centers for Disease Control and Prevention (U.S.)
Psychological Stress
Cardiac Output
Vascular Resistance
Stroke Volume
Cardiovascular Diseases
Public Health
Heart Rate

Keywords

  • Autonomic balance
  • Cardiovascular
  • Children
  • Lead
  • Stress
  • Vascular

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Toxicology

Cite this

Low-level Pb and cardiovascular responses to acute stress in children : The role of cardiac autonomic regulation. / Gump, Brooks B; MacKenzie, James A.; Bendinskas, Kestutis; Morgan, Robert; Dumas, Amy K.; Palmer, Christopher D.; Parsons, Patrick J.

In: Neurotoxicology and Teratology, Vol. 33, No. 2, 03.2011, p. 212-219.

Research output: Contribution to journalArticle

Gump, Brooks B ; MacKenzie, James A. ; Bendinskas, Kestutis ; Morgan, Robert ; Dumas, Amy K. ; Palmer, Christopher D. ; Parsons, Patrick J. / Low-level Pb and cardiovascular responses to acute stress in children : The role of cardiac autonomic regulation. In: Neurotoxicology and Teratology. 2011 ; Vol. 33, No. 2. pp. 212-219.
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