Low-level mercury in children: Associations with sleep duration and cytokines TNF-α and IL-6

Brooks B Gump, Elena Gabrikova, Kestutis Bendinskas, Amy K. Dumas, Christopher D. Palmer, Patrick J. Parsons, James A. MacKenzie

Research output: Contribution to journalArticle

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Abstract

There is a sizeable literature suggesting that mercury (Hg) exposure affects cytokine levels in humans. In addition to their signaling role in the immune system, some cytokines are also integrally associated with sleep behavior. In this cross-sectional study of 9-11 year old children ( N=100), we measured total blood Hg in whole blood, serum levels of tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), and objectively measured sleep and activity using actigraphy. Increasing blood Hg was associated with significantly shorter sleep duration and lower levels of TNF-α. IL-6 was not associated with sleep or blood Hg. This study is the first to document an association between total blood Hg and sleep (albeit a small effect), and the first to consider the associations of total blood Hg with cytokines TNF-α and IL-6 in a pediatric sample. Further research using alternative designs (e.g., time-series) is necessary to determine if there is a causal pathway linking low-level Hg exposure to sleep restriction and reduced cytokines.

Original languageEnglish (US)
Pages (from-to)228-232
Number of pages5
JournalEnvironmental Research
Volume134
DOIs
StatePublished - 2014

Fingerprint

sleep
Mercury
tumor
Interleukin-6
Sleep
Blood
Tumor Necrosis Factor-alpha
blood
Cytokines
Actigraphy
Pediatrics
Immune system
immune system
necrosis
mercury
serum
Time series
Immune System
Cross-Sectional Studies
time series

Keywords

  • Children
  • Cytokines
  • IL-6
  • Mercury
  • Sleep
  • TNF-α

ASJC Scopus subject areas

  • Environmental Science(all)
  • Biochemistry

Cite this

Gump, B. B., Gabrikova, E., Bendinskas, K., Dumas, A. K., Palmer, C. D., Parsons, P. J., & MacKenzie, J. A. (2014). Low-level mercury in children: Associations with sleep duration and cytokines TNF-α and IL-6. Environmental Research, 134, 228-232. https://doi.org/10.1016/j.envres.2014.07.026

Low-level mercury in children : Associations with sleep duration and cytokines TNF-α and IL-6. / Gump, Brooks B; Gabrikova, Elena; Bendinskas, Kestutis; Dumas, Amy K.; Palmer, Christopher D.; Parsons, Patrick J.; MacKenzie, James A.

In: Environmental Research, Vol. 134, 2014, p. 228-232.

Research output: Contribution to journalArticle

Gump, BB, Gabrikova, E, Bendinskas, K, Dumas, AK, Palmer, CD, Parsons, PJ & MacKenzie, JA 2014, 'Low-level mercury in children: Associations with sleep duration and cytokines TNF-α and IL-6', Environmental Research, vol. 134, pp. 228-232. https://doi.org/10.1016/j.envres.2014.07.026
Gump, Brooks B ; Gabrikova, Elena ; Bendinskas, Kestutis ; Dumas, Amy K. ; Palmer, Christopher D. ; Parsons, Patrick J. ; MacKenzie, James A. / Low-level mercury in children : Associations with sleep duration and cytokines TNF-α and IL-6. In: Environmental Research. 2014 ; Vol. 134. pp. 228-232.
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