TY - JOUR
T1 - Long-term effectiveness of an ultra-rapid rollout vaccination campaign with BNT162b2 on the incidence of SARS-CoV-2 infection
AU - Tschiderer, Lena
AU - Innerhofer, Hanna
AU - Seekircher, Lisa
AU - Waltle, Lisa
AU - Richter, Lukas
AU - Kimpel, Janine
AU - Lass-Flörl, Cornelia
AU - Forer, Lukas
AU - Schönherr, Sebastian
AU - Larsen, David A.
AU - Krammer, Florian
AU - Embacher-Aichhorn, Sabine
AU - Tilg, Herbert
AU - Weiss, Günter
AU - Allerberger, Franz
AU - Willeit, Peter
N1 - Publisher Copyright:
© 2024 The Author(s)
PY - 2024/11/15
Y1 - 2024/11/15
N2 - In 2021, an ultra-rapid rollout vaccination campaign in the Schwaz district, Tyrol, Austria, delivered the COVID-19 vaccine BNT162b2 to 66.9% of eligible residents (dose 1: March 11–16, dose 2: April 8–13). Alongside the campaign, we recruited 11,955 residents into the prospective study REDUCE, of whom 3,859 participated in a booster vaccination initiative (November 20–28, 2021). Over a 24-month follow-up, 1,672 participants had incident RT-PCR-confirmed SARS-CoV-2. Compared to other Tyrolean districts, effectiveness in reducing SARS-CoV-2 infection at months 1–9 versus months 10–24 was 81.6% (95% CI 80.0–83.2%; hazard ratio 0.18 [0.17–0.20]) versus 38.2% (35.8–40.6%; 0.62 [0.59–0.64]) among REDUCE participants, and 22.5% (20.5–24.4%; 0.78 [0.76–0.80]) versus 17.0% (16.2–17.8%; 0.83 [0.82–0.84]) in the entire Schwaz district, with substantial variability during follow-up. By March 2023, 61% of Schwaz residents had received booster vaccination versus 55% in other Tyrolean districts. Consequently, vaccinating individuals at high pace effectively reduced SARS-CoV-2 infections and achieved higher vaccination coverage.
AB - In 2021, an ultra-rapid rollout vaccination campaign in the Schwaz district, Tyrol, Austria, delivered the COVID-19 vaccine BNT162b2 to 66.9% of eligible residents (dose 1: March 11–16, dose 2: April 8–13). Alongside the campaign, we recruited 11,955 residents into the prospective study REDUCE, of whom 3,859 participated in a booster vaccination initiative (November 20–28, 2021). Over a 24-month follow-up, 1,672 participants had incident RT-PCR-confirmed SARS-CoV-2. Compared to other Tyrolean districts, effectiveness in reducing SARS-CoV-2 infection at months 1–9 versus months 10–24 was 81.6% (95% CI 80.0–83.2%; hazard ratio 0.18 [0.17–0.20]) versus 38.2% (35.8–40.6%; 0.62 [0.59–0.64]) among REDUCE participants, and 22.5% (20.5–24.4%; 0.78 [0.76–0.80]) versus 17.0% (16.2–17.8%; 0.83 [0.82–0.84]) in the entire Schwaz district, with substantial variability during follow-up. By March 2023, 61% of Schwaz residents had received booster vaccination versus 55% in other Tyrolean districts. Consequently, vaccinating individuals at high pace effectively reduced SARS-CoV-2 infections and achieved higher vaccination coverage.
KW - Health sciences
KW - Public health
KW - Virology
UR - http://www.scopus.com/inward/record.url?scp=85207767420&partnerID=8YFLogxK
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U2 - 10.1016/j.isci.2024.111117
DO - 10.1016/j.isci.2024.111117
M3 - Article
AN - SCOPUS:85207767420
SN - 2589-0042
VL - 27
JO - iScience
JF - iScience
IS - 11
M1 - 111117
ER -