Limits on inferring genetic adaptation to high altitude in Himalayan and Andean populations

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18 Scopus citations

Abstract

Tom D. Brutsaert. Limits on inferring genetic adaptation to high altitude in Himalayan and Andean populations. High Alt Med Biol 2:211-225, 2001.-Many physiological and anthropological studies have investigated the unique Andean and Himalayan populations that have resided for many hundreds of generations at high altitude (HA). A nonscientific survey of the extant literature reveals a relatively liberal tradition of inferring genetic (evolutionary) adaptation to HA in these groups, often based on limited evidence and/or based on study designs insufficient to fully address the issue. In order to provide some perspective, I review relevant methodological issues that should be considered before evolutionary inference is made. On the whole, this paper takes a conservative stance and cautions against evolutionary inference based on the serious limitations of currently applied research approaches.

Original languageEnglish (US)
Pages (from-to)211-225
Number of pages15
JournalHigh Altitude Medicine and Biology
Volume2
Issue number2
DOIs
StatePublished - Aug 6 2001
Externally publishedYes

Keywords

  • Acclimatization
  • Developmental adaptation
  • Hypoxia
  • Natural selection

ASJC Scopus subject areas

  • Physiology
  • Public Health, Environmental and Occupational Health

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