Tom D. Brutsaert. Limits on inferring genetic adaptation to high altitude in Himalayan and Andean populations. High Alt Med Biol 2:211-225, 2001.-Many physiological and anthropological studies have investigated the unique Andean and Himalayan populations that have resided for many hundreds of generations at high altitude (HA). A nonscientific survey of the extant literature reveals a relatively liberal tradition of inferring genetic (evolutionary) adaptation to HA in these groups, often based on limited evidence and/or based on study designs insufficient to fully address the issue. In order to provide some perspective, I review relevant methodological issues that should be considered before evolutionary inference is made. On the whole, this paper takes a conservative stance and cautions against evolutionary inference based on the serious limitations of currently applied research approaches.
- Developmental adaptation
- Natural selection
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health