Light-assisted direct-write of 3D functional biomaterials

Kolin C. Hribar, Pranav Soman, John Warner, Peter Chung, Shaochen Chen

Research output: Contribution to journalReview article

112 Scopus citations

Abstract

Light-assisted 3D direct-printing of biomaterials and cellular-scaffolds has the potential to develop novel lab-on-a-chip devices (LOCs) for a variety of biomedical applications, from drug discovery and diagnostic testing to in vitro tissue engineering and regeneration. Direct-writing describes a broad family of fabrication methods that typically employ computer-controlled translational stages to manufacture structures at multi-length scales. This review focuses on light-assisted direct-write fabrication for generating 3D functional scaffolds with precise micro- and nano-architecture, using both synthetic as well as naturally derived biomaterials. Two bioprinting approaches are discussed in detail-projection printing and laser-based systems-where each method is capable of modulating multiple scaffold parameters, such as 3D architecture, mechanical properties (e.g. stiffness), Poisson's ratio, chemical gradients, biological cell distributions, and porosity. The light-assisted direct-writing techniques described in this review provide the reader with alternative approaches to fabricate 3D biomaterials for utility in LOCs.

Original languageEnglish (US)
Pages (from-to)268-275
Number of pages8
JournalLab on a Chip
Volume14
Issue number2
DOIs
StatePublished - Jan 21 2014
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Light-assisted direct-write of 3D functional biomaterials'. Together they form a unique fingerprint.

  • Cite this

    Hribar, K. C., Soman, P., Warner, J., Chung, P., & Chen, S. (2014). Light-assisted direct-write of 3D functional biomaterials. Lab on a Chip, 14(2), 268-275. https://doi.org/10.1039/c3lc50634g