TY - JOUR
T1 - Life events and alcohol use disorder clinical course
T2 - Modeling the dynamic association
AU - Krenek, Marketa
AU - Prince, Mark A.
AU - Maisto, Stephen A.
N1 - Funding Information:
This work was performed in partial fulfillment of the requirements for the PhD degree of the first author under the supervision of the third author at Syracuse University. Preparation of this manuscript was supported in part by a grant from NIAAA ( #2 K05 AA016928 ) awarded to Stephen A. Maisto, PhD.
Publisher Copyright:
© 2017
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Background Despite over 35 years of study, the relationship between life events (LEs) and alcohol use disorder (AUD) treatment outcome lacks consistent empirical support, which may be due to a lack of theoretically driven designs and corresponding statistical analyses. The purpose of this study was to elucidate the LEs-AUD treatment outcome relationship by statistically modeling the dynamic relationship between negative LEs and alcohol use post-treatment, as it is conceptualized within the dynamic model of relapse. Methods Existing longitudinal data from 417 AUD treatment-seeking adults were randomly assigned to two demographically comparable samples. One sample (N = 208) was used to estimate a series of dynamic bivariate latent change score models that differentially relate latent indicators of distal and proximal negative LEs (i.e., events subjectively rated as negative) and percent heavy drinking days across 12 months. Cross-validation was conducted on the second sample (N = 209). Results Findings indicated that distal negative LEs were positively associated with a greater increase in negative LEs, but not heavy drinking, over the subsequent 12 months. Proximal negative LEs were significantly associated with subsequent increases in heavy drinking, though heavy drinking was not a determinant of change in negative LEs. These findings were cross-validated with the second sample. Conclusions This study provides initial justification for the further study of the LEs-alcohol use relationship as it is described in the dynamic model of relapse.
AB - Background Despite over 35 years of study, the relationship between life events (LEs) and alcohol use disorder (AUD) treatment outcome lacks consistent empirical support, which may be due to a lack of theoretically driven designs and corresponding statistical analyses. The purpose of this study was to elucidate the LEs-AUD treatment outcome relationship by statistically modeling the dynamic relationship between negative LEs and alcohol use post-treatment, as it is conceptualized within the dynamic model of relapse. Methods Existing longitudinal data from 417 AUD treatment-seeking adults were randomly assigned to two demographically comparable samples. One sample (N = 208) was used to estimate a series of dynamic bivariate latent change score models that differentially relate latent indicators of distal and proximal negative LEs (i.e., events subjectively rated as negative) and percent heavy drinking days across 12 months. Cross-validation was conducted on the second sample (N = 209). Results Findings indicated that distal negative LEs were positively associated with a greater increase in negative LEs, but not heavy drinking, over the subsequent 12 months. Proximal negative LEs were significantly associated with subsequent increases in heavy drinking, though heavy drinking was not a determinant of change in negative LEs. These findings were cross-validated with the second sample. Conclusions This study provides initial justification for the further study of the LEs-alcohol use relationship as it is described in the dynamic model of relapse.
KW - Alcohol use disorder
KW - Bivariate latent change score analysis
KW - Heavy drinking
KW - Negative life events
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U2 - 10.1016/j.drugalcdep.2017.08.004
DO - 10.1016/j.drugalcdep.2017.08.004
M3 - Article
C2 - 28888153
AN - SCOPUS:85032941458
SN - 0376-8716
VL - 180
SP - 137
EP - 143
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
ER -