@article{870716da275149fd9c50eda18db02310,
title = "Leveraging risk maps of malaria vector abundance to guide control efforts reduces malaria incidence in Eastern Province, Zambia",
abstract = "Although transmission of malaria and other mosquito-borne diseases is geographically heterogeneous, in sub-Saharan Africa risk maps are rarely used to determine which communities receive vector control interventions. We compared outcomes in areas receiving different indoor residual spray (IRS) strategies in Eastern Province, Zambia: (1) concentrating IRS interventions within a geographical area, (2) prioritizing communities to receive IRS based on predicted probabilities of Anopheles funestus, and (3) prioritizing communities to receive IRS based on observed malaria incidence at nearby health centers. Here we show that the use of predicted probabilities of An. funestus to guide IRS implementation saw the largest decrease in malaria incidence at health centers, a 13% reduction (95% confidence interval = 5–21%) compared to concentrating IRS geographically and a 37% reduction (95% confidence interval = 30–44%) compared to targeting IRS based on health facility incidence. These results suggest that vector control programs could produce better outcomes by prioritizing IRS according to malaria-vector risk maps.",
author = "Larsen, {David A.} and Anne Martin and Derek Pollard and Nielsen, {Carrie F.} and Busiku Hamainza and Matthew Burns and Jennifer Stevenson and Anna Winters",
note = "Funding Information: indoor residual spraying. IRS was implemented in the study districts with funding from the President{\textquoteright}s Malaria Initiative (PMI) and in accordance with the Zambian Ministry of Health/National Malaria Elimination Program and PMI Africa Indoor Residual Spraying (AIRS) program standards supplemented with mSpray, which is described in detail elsewhere17,26–28. IRS was conducted using pirimiphos-methyl (Actellic 300 CS). The funding for spray operations was independent of the trial; study investigators only served in an advisory capacity to actual implementation of the intervention. IRS in Eastern Province was implemented during November and December 2017, the months preceding heavy rains. According to MIS data previous campaigns have covered around 50% of total structures within Eastern Province (with higher coverage of structures targeted), and we expected a similar level of coverage within trial districts. Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = dec,
day = "1",
doi = "10.1038/s41598-020-66968-w",
language = "English (US)",
volume = "10",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}