Laser-guidance based detection of cells with single-gene modification

Zhen Ma, Karen J.L. Burg, Yanzhang Wei, X. C. Yuan, Xiang Peng, Bruce Z. Gao

Research output: Contribution to journalArticle

19 Scopus citations


An optical method with single-gene sensitivity for cell detection based on laser guidance was explored. Guided by the optical force from a weakly focused laser beam, a cell will move along the laser axis. Cells with different properties experience different optical forces and thus guidance speeds. The guidance speeds of the TC-1 cell and its genetically modified counterpart with only one gene change, L-10 cell, were studied under the same conditions. The results demonstrated that this laser guidance-based speed-measurement method can precisely distinguish cells that differ by only one gene.

Original languageEnglish (US)
Article number213902
JournalApplied Physics Letters
Issue number21
StatePublished - 2008

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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  • Cite this

    Ma, Z., Burg, K. J. L., Wei, Y., Yuan, X. C., Peng, X., & Gao, B. Z. (2008). Laser-guidance based detection of cells with single-gene modification. Applied Physics Letters, 92(21), [213902].