Laser-assisted biofabrication in tissue engineering and regenerative medicine

Sangmo Koo, Samantha M. Santoni, Bruce Z. Gao, Costas P. Grigoropoulos, Zhen Ma

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Controlling the spatial arrangement of biomaterials and living cells provides the foundation for fabricating complex biological systems. Such level of spatial resolution (less than 10 Âm) is difficult to be obtained through conventional cell processing techniques, which lack the precision, reproducibility, automation, and speed required for the rapid fabrication of engineered tissue constructs. Recently, laser-assisted biofabrication techniques are being intensively developed with the use of computer-aided processes for patterning and assembling both living and nonliving materials with prescribed 2D or 3D organization. In this review, we discuss laser-assisted fabrication methods, including laser tweezers, multi-photon polymerization, laser-induced forward transfer (LIFT), matrix assisted pulsed laser evaporation (MAPLE), and laser ablation as well as their applications in biological science and biomedical engineering. These advanced technologies enable the precise manipulation of in vitro cellular microenvironments and the ability to engineer functional tissue constructs with high complexity and heterogeneity, which serve in regenerative medicine, pharmacology, and basic cell biology studies.

Original languageEnglish (US)
Pages (from-to)128-142
Number of pages15
JournalJournal of Materials Research
Volume32
Issue number1
DOIs
StatePublished - Jan 13 2017

Keywords

  • biomaterial
  • laser
  • microstructure

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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