Kemp Eliminases of the AlleyCat Family Possess High Substrate Promiscuity

Elizabeth A. Caselle, Jennifer H. Yoon, Sagar Bhattacharya, Joel J.L. Rempillo, Zsófia Lengyel, Areetha D'Souza, Yurii S. Moroz, Patricia L. Tolbert, Alexander N. Volkov, Marcello Forconi, Carlos A. Castañeda, Olga V. Makhlynets, Ivan V. Korendovych

Research output: Contribution to journalComment/debate

Abstract

The front cover artwork for Issue 05/2019 is provided by the Korendoych and the Makhlynets Labs at Syracuse University (USA) in collaboration with the VIB Centre for Structural Biology (Belgium), College of Charleston (USA) and Kyiv National University (Ukraine). The image shows AlleyCat2, a minimalist allosterically regulated Kemp eliminase, efficiently promoting ring opening of leflunomide, an immunosuppresant. Small libraries of designed catalysts provide fertile ground for discovering new reactivities. See the Communication itself at https://doi.org/10.1002/cctc.201801994.

Original languageEnglish (US)
Number of pages1
JournalChemCatChem
Volume11
Issue number5
DOIs
StatePublished - Mar 6 2019

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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  • Cite this

    Caselle, E. A., Yoon, J. H., Bhattacharya, S., Rempillo, J. J. L., Lengyel, Z., D'Souza, A., Moroz, Y. S., Tolbert, P. L., Volkov, A. N., Forconi, M., Castañeda, C. A., Makhlynets, O. V., & Korendovych, I. V. (2019). Kemp Eliminases of the AlleyCat Family Possess High Substrate Promiscuity. ChemCatChem, 11(5). https://doi.org/10.1002/cctc.201900269