TY - JOUR
T1 - Kemp Eliminases of the AlleyCat Family Possess High Substrate Promiscuity
AU - Caselle, Elizabeth A.
AU - Yoon, Jennifer H.
AU - Bhattacharya, Sagar
AU - Rempillo, Joel J.L.
AU - Lengyel, Zsófia
AU - D'Souza, Areetha
AU - Moroz, Yurii S.
AU - Tolbert, Patricia L.
AU - Volkov, Alexander N.
AU - Forconi, Marcello
AU - Castañeda, Carlos A.
AU - Makhlynets, Olga V.
AU - Korendovych, Ivan V.
N1 - Funding Information:
We thank Prof. Dr. Patrick J. Bednarsky (University of Greifswald) for bringing chemical similarity of benzisoxazoles and leflunomide to our attention. This work was supported by the NIH, the NSF, the College of Charleston, the Howard Hughes Medical Institute, the ORAU, the Nappi Family and the Alexander von Humboldt Foundation.
Publisher Copyright:
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2019/3/6
Y1 - 2019/3/6
N2 - The front cover artwork for Issue 05/2019 is provided by the Korendoych and the Makhlynets Labs at Syracuse University (USA) in collaboration with the VIB Centre for Structural Biology (Belgium), College of Charleston (USA) and Kyiv National University (Ukraine). The image shows AlleyCat2, a minimalist allosterically regulated Kemp eliminase, efficiently promoting ring opening of leflunomide, an immunosuppresant. Small libraries of designed catalysts provide fertile ground for discovering new reactivities. See the Communication itself at https://doi.org/10.1002/cctc.201801994.
AB - The front cover artwork for Issue 05/2019 is provided by the Korendoych and the Makhlynets Labs at Syracuse University (USA) in collaboration with the VIB Centre for Structural Biology (Belgium), College of Charleston (USA) and Kyiv National University (Ukraine). The image shows AlleyCat2, a minimalist allosterically regulated Kemp eliminase, efficiently promoting ring opening of leflunomide, an immunosuppresant. Small libraries of designed catalysts provide fertile ground for discovering new reactivities. See the Communication itself at https://doi.org/10.1002/cctc.201801994.
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U2 - 10.1002/cctc.201900269
DO - 10.1002/cctc.201900269
M3 - Comment/debate
AN - SCOPUS:85062495099
VL - 11
SP - 1377
JO - ChemCatChem
JF - ChemCatChem
SN - 1867-3880
IS - 5
ER -