Kemp Eliminases of the AlleyCat Family Possess High Substrate Promiscuity

Elizabeth A. Caselle; Jennifer H. Yoon; Sagar Bhattacharya; Joel J.L. Rempillo; Zsófia Lengyel; Areetha D'Souza; Yurii S. Moroz; Patricia L. Tolbert; Alexander N. Volkov; Marcello Forconi; Carlos A. Castañeda; Olga V. Makhlynets; Ivan V. Korendovych

doi:10.1002/cctc.201900269

Kemp Eliminases of the AlleyCat Family Possess High Substrate Promiscuity

Elizabeth A. Caselle, Jennifer H. Yoon, Sagar Bhattacharya, Joel J.L. Rempillo, Zsófia Lengyel, Areetha D'Souza, Yurii S. Moroz, Patricia L. Tolbert, Alexander N. Volkov, Marcello Forconi, Carlos A. Castañeda, Olga V. Makhlynets, Ivan V. Korendovych

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

The front cover artwork for Issue 05/2019 is provided by the Korendoych and the Makhlynets Labs at Syracuse University (USA) in collaboration with the VIB Centre for Structural Biology (Belgium), College of Charleston (USA) and Kyiv National University (Ukraine). The image shows AlleyCat2, a minimalist allosterically regulated Kemp eliminase, efficiently promoting ring opening of leflunomide, an immunosuppresant. Small libraries of designed catalysts provide fertile ground for discovering new reactivities. See the Communication itself at https://doi.org/10.1002/cctc.201801994.

Original language	English (US)
Pages (from-to)	1377
Number of pages	1
Journal	ChemCatChem
Volume	11
Issue number	5
DOIs	https://doi.org/10.1002/cctc.201900269
State	Published - Mar 6 2019

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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title = "Kemp Eliminases of the AlleyCat Family Possess High Substrate Promiscuity",

abstract = "The front cover artwork for Issue 05/2019 is provided by the Korendoych and the Makhlynets Labs at Syracuse University (USA) in collaboration with the VIB Centre for Structural Biology (Belgium), College of Charleston (USA) and Kyiv National University (Ukraine). The image shows AlleyCat2, a minimalist allosterically regulated Kemp eliminase, efficiently promoting ring opening of leflunomide, an immunosuppresant. Small libraries of designed catalysts provide fertile ground for discovering new reactivities. See the Communication itself at https://doi.org/10.1002/cctc.201801994.",

author = "Caselle, {Elizabeth A.} and Yoon, {Jennifer H.} and Sagar Bhattacharya and Rempillo, {Joel J.L.} and Zs{\'o}fia Lengyel and Areetha D'Souza and Moroz, {Yurii S.} and Tolbert, {Patricia L.} and Volkov, {Alexander N.} and Marcello Forconi and Casta{\~n}eda, {Carlos A.} and Makhlynets, {Olga V.} and Korendovych, {Ivan V.}",

note = "Funding Information: We thank Prof. Dr. Patrick J. Bednarsky (University of Greifswald) for bringing chemical similarity of benzisoxazoles and leflunomide to our attention. This work was supported by the NIH, the NSF, the College of Charleston, the Howard Hughes Medical Institute, the ORAU, the Nappi Family and the Alexander von Humboldt Foundation. Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2019",

month = mar,

day = "6",

doi = "10.1002/cctc.201900269",

language = "English (US)",

volume = "11",

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T1 - Kemp Eliminases of the AlleyCat Family Possess High Substrate Promiscuity

AU - Caselle, Elizabeth A.

AU - Yoon, Jennifer H.

AU - Bhattacharya, Sagar

AU - Rempillo, Joel J.L.

AU - Lengyel, Zsófia

AU - D'Souza, Areetha

AU - Moroz, Yurii S.

AU - Tolbert, Patricia L.

AU - Volkov, Alexander N.

AU - Forconi, Marcello

AU - Castañeda, Carlos A.

AU - Makhlynets, Olga V.

AU - Korendovych, Ivan V.

N1 - Funding Information: We thank Prof. Dr. Patrick J. Bednarsky (University of Greifswald) for bringing chemical similarity of benzisoxazoles and leflunomide to our attention. This work was supported by the NIH, the NSF, the College of Charleston, the Howard Hughes Medical Institute, the ORAU, the Nappi Family and the Alexander von Humboldt Foundation. Publisher Copyright: © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2019/3/6

Y1 - 2019/3/6

N2 - The front cover artwork for Issue 05/2019 is provided by the Korendoych and the Makhlynets Labs at Syracuse University (USA) in collaboration with the VIB Centre for Structural Biology (Belgium), College of Charleston (USA) and Kyiv National University (Ukraine). The image shows AlleyCat2, a minimalist allosterically regulated Kemp eliminase, efficiently promoting ring opening of leflunomide, an immunosuppresant. Small libraries of designed catalysts provide fertile ground for discovering new reactivities. See the Communication itself at https://doi.org/10.1002/cctc.201801994.

AB - The front cover artwork for Issue 05/2019 is provided by the Korendoych and the Makhlynets Labs at Syracuse University (USA) in collaboration with the VIB Centre for Structural Biology (Belgium), College of Charleston (USA) and Kyiv National University (Ukraine). The image shows AlleyCat2, a minimalist allosterically regulated Kemp eliminase, efficiently promoting ring opening of leflunomide, an immunosuppresant. Small libraries of designed catalysts provide fertile ground for discovering new reactivities. See the Communication itself at https://doi.org/10.1002/cctc.201801994.

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JF - ChemCatChem

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Kemp Eliminases of the AlleyCat Family Possess High Substrate Promiscuity

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