Intra-septal infusions of glucose potentiate inhibitory avoidance deficits when co-infused with GABA agonist muscimol

Marise B. Parent, Paul E. Gold

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

This experiment examined the effects of co-infusions of glucose with the α-aminobutyric acid (GABA) agonist muscimol into the medial septum on memory for inhibitory avoidance learning. Co-infusions of muscimol (3 nmol) and glucose (33 nmol) impaired memory, but neither drug did so when administered alone. Thus, although glucose typically reverses memory deficits, these results indicate that glucose potentiates the memory-impairing effects of a GABA agonist.

Original languageEnglish (US)
Pages (from-to)317-320
Number of pages4
JournalBrain Research
Volume745
Issue number1-2
DOIs
StatePublished - Jan 16 1997
Externally publishedYes

Keywords

  • Glucose
  • Inhibitory avoidance
  • Medial septum
  • Memory
  • Muscimol
  • γ-Aminobutyric acid (GABA)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Intra-septal infusions of glucose potentiate inhibitory avoidance deficits when co-infused with GABA agonist muscimol'. Together they form a unique fingerprint.

  • Cite this