Intra-septal infusions of glucose potentiate inhibitory avoidance deficits when co-infused with GABA agonist muscimol

Marise B. Parent; Paul E. Gold

doi:10.1016/S0006-8993(96)01206-1

Intra-septal infusions of glucose potentiate inhibitory avoidance deficits when co-infused with GABA agonist muscimol

Marise B. Parent, Paul E. Gold

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

This experiment examined the effects of co-infusions of glucose with the α-aminobutyric acid (GABA) agonist muscimol into the medial septum on memory for inhibitory avoidance learning. Co-infusions of muscimol (3 nmol) and glucose (33 nmol) impaired memory, but neither drug did so when administered alone. Thus, although glucose typically reverses memory deficits, these results indicate that glucose potentiates the memory-impairing effects of a GABA agonist.

Original language	English (US)
Pages (from-to)	317-320
Number of pages	4
Journal	Brain Research
Volume	745
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(96)01206-1
State	Published - Jan 16 1997
Externally published	Yes

Keywords

Glucose
Inhibitory avoidance
Medial septum
Memory
Muscimol
γ-Aminobutyric acid (GABA)

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(96)01206-1

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title = "Intra-septal infusions of glucose potentiate inhibitory avoidance deficits when co-infused with GABA agonist muscimol",

abstract = "This experiment examined the effects of co-infusions of glucose with the α-aminobutyric acid (GABA) agonist muscimol into the medial septum on memory for inhibitory avoidance learning. Co-infusions of muscimol (3 nmol) and glucose (33 nmol) impaired memory, but neither drug did so when administered alone. Thus, although glucose typically reverses memory deficits, these results indicate that glucose potentiates the memory-impairing effects of a GABA agonist.",

keywords = "Glucose, Inhibitory avoidance, Medial septum, Memory, Muscimol, γ-Aminobutyric acid (GABA)",

author = "Parent, {Marise B.} and Gold, {Paul E.}",

note = "Funding Information: This research was supported by NIA (AG07648, AG05658), NINDS (NS32914), and NIH (HD07323). We thank Lauren M. Chamberlain and Vely A. Louis for their invaluable technical assistance. ",

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T1 - Intra-septal infusions of glucose potentiate inhibitory avoidance deficits when co-infused with GABA agonist muscimol

AU - Parent, Marise B.

AU - Gold, Paul E.

N1 - Funding Information: This research was supported by NIA (AG07648, AG05658), NINDS (NS32914), and NIH (HD07323). We thank Lauren M. Chamberlain and Vely A. Louis for their invaluable technical assistance.

PY - 1997/1/16

Y1 - 1997/1/16

N2 - This experiment examined the effects of co-infusions of glucose with the α-aminobutyric acid (GABA) agonist muscimol into the medial septum on memory for inhibitory avoidance learning. Co-infusions of muscimol (3 nmol) and glucose (33 nmol) impaired memory, but neither drug did so when administered alone. Thus, although glucose typically reverses memory deficits, these results indicate that glucose potentiates the memory-impairing effects of a GABA agonist.

AB - This experiment examined the effects of co-infusions of glucose with the α-aminobutyric acid (GABA) agonist muscimol into the medial septum on memory for inhibitory avoidance learning. Co-infusions of muscimol (3 nmol) and glucose (33 nmol) impaired memory, but neither drug did so when administered alone. Thus, although glucose typically reverses memory deficits, these results indicate that glucose potentiates the memory-impairing effects of a GABA agonist.

KW - Glucose

KW - Inhibitory avoidance

KW - Medial septum

KW - Memory

KW - Muscimol

KW - γ-Aminobutyric acid (GABA)

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Intra-septal infusions of glucose potentiate inhibitory avoidance deficits when co-infused with GABA agonist muscimol

Abstract

Keywords

ASJC Scopus subject areas

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