Intra-amygdala kinase inhibitors disrupt retention of a learned avoidance response in rats

David L. Walker, Paul E. Gold

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

To assess the involvement of intra-amygdala kinase activity in aversively motivated learning, rats received intracranial injections of polymixin B sulfate (PMXB) - a protein kinase C (PKC) and calcium/calmodulin-dependent kinase II inhibitor - immediately after inhibitory avoidance training. When tested 48 h later, retention was significantly impaired relative to vehicle-injected controls. Delayed injections (2 h posttraining) and injections made dorsal to the amygdala were ineffective. Immediate posttraining injections of the more selective PKC inhibitor, NPC 15437, also impaired retention. These results suggest that intra-amygdala protein phosphorylation must occur soon after training for learned avoidance responses to be successfully retained.

Original languageEnglish (US)
Pages (from-to)255-258
Number of pages4
JournalNeuroscience Letters
Volume176
Issue number2
DOIs
StatePublished - Aug 1 1994
Externally publishedYes

Keywords

  • Amygdala
  • Inhibitory avoidance
  • Kinase
  • Learning
  • Memory
  • NPC 15437
  • PMXB
  • Protein kinase C

ASJC Scopus subject areas

  • Neuroscience(all)

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