Intermodality nonrigid breast-image registration

Ioana Coman, Andrzej Krol, David Feiglin, Edward Lipson, James Mandel, Karl Baum, Mehmet Unlu, Wei Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Abstract

We investigated nonrigid co-registration of PET and MR breast images to improve diagnostic specificity in difficult-to-interpret mammograms, and ultimately to avoid biopsy. A deformable breast model based on a finite-element method (FEM) was employed. The FEM "loads" were taken as the observed intermodal displacements of several fiducial skin markers placed on the breast and visible in PET and MRI. The analogy between orthogonal components of the displacement field and the temperature differences in a steady-state heat transfer (SSHT) in solids was adopted. The model allows estimation of the intermodal breast deformation for every location within the breast. To test our model, an elastic breast phantom with simulated internal "lesions" and external markers was imaged with PET and MRI. We estimated fiducial- and target-registration errors vs. number and location of the fiducials. We established that SSHT approach using external fiducial markers is accurate to within ∼5 mm.

Original languageEnglish (US)
Title of host publication2004 2nd IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationMacro to Nano
Pages1440-1442
Number of pages3
StatePublished - Dec 1 2004
Event2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano - Arlington, VA, United States
Duration: Apr 15 2004Apr 18 2004

Publication series

Name2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
Volume2

Other

Other2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
CountryUnited States
CityArlington, VA
Period4/15/044/18/04

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Coman, I., Krol, A., Feiglin, D., Lipson, E., Mandel, J., Baum, K., Unlu, M., & Li, W. (2004). Intermodality nonrigid breast-image registration. In 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano (pp. 1440-1442). (2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano; Vol. 2).