Interleukin-1β: A bridge between inflammation and excitotoxicity?

Birgit Fogal, Sandra J. Hewett

Research output: Contribution to journalReview article

83 Scopus citations

Abstract

Interleukin-1 (IL-1) is a proinflammatory cytokine released by many cell types that acts in both an autocrine and/or paracrine fashion. While IL-1 is best described as an important mediator of the peripheral immune response during infection and inflammation, increasing evidence implicates IL-1 signaling in the pathogenesis of several neurological disorders. The biochemical pathway(s) by which this cytokine contributes to brain injury remain(s) largely unidentified. Herein, we review the evidence that demonstrates the contribution of IL-1β to the pathogenesis of both acute and chronic neurological disorders. Further, we highlight data that leads us to propose IL-1β as the missing mechanistic link between a potential beneficial inflammatory response and detrimental glutamate excitotoxicity.

Original languageEnglish (US)
Pages (from-to)1-23
Number of pages23
JournalJournal of Neurochemistry
Volume106
Issue number1
DOIs
StatePublished - Jul 1 2008
Externally publishedYes

Keywords

  • Excitotoxicity
  • Glutamate
  • Interleukin-1β
  • Neuroinflammation
  • Oxidative stress
  • System x

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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