Interactive effects of fitness and hormone treatment on brain health in postmenopausal women

Kirk I. Erickson, Stanley J. Colcombe, Steriani Elavsky, Edward McAuley, Donna L. Korol, Paige E. Scalf, Arthur F. Kramer

Research output: Contribution to journalArticlepeer-review

117 Scopus citations


Recent research in rodents suggests that extended and chronic hormone therapy can exacerbate memory impairments and irreversibly damage cells. However, aerobic fitness regimens have been shown to spare brain tissue and cognitive function. In addition, interactions between estrogen treatment and exercise have been reported in rodents. However, whether aerobic fitness and hormone treatments show interactive effects on human brain tissue and cognition has yet to be determined. Here we report two unique and important results: (a) HRT treatment up to 10 years in duration spares gray matter in prefrontal cortex and is associated with better performance on measures of executive function, whereas HRT treatment beyond 10 years in duration increases the degree of prefrontal deterioration and amplifies the decline on measures of executive functioning (b) higher fitness levels augment the effects of shorter durations of hormone treatment and ameliorate the declines associated with prolonged hormone treatment.

Original languageEnglish (US)
Pages (from-to)179-185
Number of pages7
JournalNeurobiology of Aging
Issue number2
StatePublished - Feb 2007
Externally publishedYes


  • Aging
  • Brain
  • Estrogen
  • Executive function
  • Exercise
  • Fitness
  • Hormones
  • Prefrontal cortex

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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