Interactive effects of fitness and hormone treatment on brain health in postmenopausal women

Kirk I. Erickson; Stanley J. Colcombe; Steriani Elavsky; Edward McAuley; Donna L. Korol; Paige E. Scalf; Arthur F. Kramer

doi:10.1016/j.neurobiolaging.2005.11.016

Interactive effects of fitness and hormone treatment on brain health in postmenopausal women

Kirk I. Erickson, Stanley J. Colcombe, Steriani Elavsky, Edward McAuley, Donna L. Korol, Paige E. Scalf, Arthur F. Kramer

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

Recent research in rodents suggests that extended and chronic hormone therapy can exacerbate memory impairments and irreversibly damage cells. However, aerobic fitness regimens have been shown to spare brain tissue and cognitive function. In addition, interactions between estrogen treatment and exercise have been reported in rodents. However, whether aerobic fitness and hormone treatments show interactive effects on human brain tissue and cognition has yet to be determined. Here we report two unique and important results: (a) HRT treatment up to 10 years in duration spares gray matter in prefrontal cortex and is associated with better performance on measures of executive function, whereas HRT treatment beyond 10 years in duration increases the degree of prefrontal deterioration and amplifies the decline on measures of executive functioning (b) higher fitness levels augment the effects of shorter durations of hormone treatment and ameliorate the declines associated with prolonged hormone treatment.

Original language	English (US)
Pages (from-to)	179-185
Number of pages	7
Journal	Neurobiology of Aging
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/j.neurobiolaging.2005.11.016
State	Published - Feb 2007
Externally published	Yes

Keywords

Aging
Brain
Estrogen
Executive function
Exercise
Fitness
Hormones
Prefrontal cortex

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

Access to Document

10.1016/j.neurobiolaging.2005.11.016

Cite this

@article{690dd9c0b847413ebf573dc3b5cbc595,

title = "Interactive effects of fitness and hormone treatment on brain health in postmenopausal women",

abstract = "Recent research in rodents suggests that extended and chronic hormone therapy can exacerbate memory impairments and irreversibly damage cells. However, aerobic fitness regimens have been shown to spare brain tissue and cognitive function. In addition, interactions between estrogen treatment and exercise have been reported in rodents. However, whether aerobic fitness and hormone treatments show interactive effects on human brain tissue and cognition has yet to be determined. Here we report two unique and important results: (a) HRT treatment up to 10 years in duration spares gray matter in prefrontal cortex and is associated with better performance on measures of executive function, whereas HRT treatment beyond 10 years in duration increases the degree of prefrontal deterioration and amplifies the decline on measures of executive functioning (b) higher fitness levels augment the effects of shorter durations of hormone treatment and ameliorate the declines associated with prolonged hormone treatment.",

keywords = "Aging, Brain, Estrogen, Executive function, Exercise, Fitness, Hormones, Prefrontal cortex",

author = "Erickson, {Kirk I.} and Colcombe, {Stanley J.} and Steriani Elavsky and Edward McAuley and Korol, {Donna L.} and Scalf, {Paige E.} and Kramer, {Arthur F.}",

note = "Funding Information: We would like to thank the following people for their assistance in collection of the data: Barbara Suever, Holly Tracy, Nancy Dodge, Tracey Wszalek, and Britt Caldwell. This research was supported by grants from the National Institutes on Aging (RO1 AG025667) and the Institute for the Study of Aging. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2007",

month = feb,

doi = "10.1016/j.neurobiolaging.2005.11.016",

language = "English (US)",

volume = "28",

pages = "179--185",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Interactive effects of fitness and hormone treatment on brain health in postmenopausal women

AU - Erickson, Kirk I.

AU - Colcombe, Stanley J.

AU - Elavsky, Steriani

AU - McAuley, Edward

AU - Korol, Donna L.

AU - Scalf, Paige E.

AU - Kramer, Arthur F.

N1 - Funding Information: We would like to thank the following people for their assistance in collection of the data: Barbara Suever, Holly Tracy, Nancy Dodge, Tracey Wszalek, and Britt Caldwell. This research was supported by grants from the National Institutes on Aging (RO1 AG025667) and the Institute for the Study of Aging. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2007/2

Y1 - 2007/2

N2 - Recent research in rodents suggests that extended and chronic hormone therapy can exacerbate memory impairments and irreversibly damage cells. However, aerobic fitness regimens have been shown to spare brain tissue and cognitive function. In addition, interactions between estrogen treatment and exercise have been reported in rodents. However, whether aerobic fitness and hormone treatments show interactive effects on human brain tissue and cognition has yet to be determined. Here we report two unique and important results: (a) HRT treatment up to 10 years in duration spares gray matter in prefrontal cortex and is associated with better performance on measures of executive function, whereas HRT treatment beyond 10 years in duration increases the degree of prefrontal deterioration and amplifies the decline on measures of executive functioning (b) higher fitness levels augment the effects of shorter durations of hormone treatment and ameliorate the declines associated with prolonged hormone treatment.

AB - Recent research in rodents suggests that extended and chronic hormone therapy can exacerbate memory impairments and irreversibly damage cells. However, aerobic fitness regimens have been shown to spare brain tissue and cognitive function. In addition, interactions between estrogen treatment and exercise have been reported in rodents. However, whether aerobic fitness and hormone treatments show interactive effects on human brain tissue and cognition has yet to be determined. Here we report two unique and important results: (a) HRT treatment up to 10 years in duration spares gray matter in prefrontal cortex and is associated with better performance on measures of executive function, whereas HRT treatment beyond 10 years in duration increases the degree of prefrontal deterioration and amplifies the decline on measures of executive functioning (b) higher fitness levels augment the effects of shorter durations of hormone treatment and ameliorate the declines associated with prolonged hormone treatment.

KW - Aging

KW - Brain

KW - Estrogen

KW - Executive function

KW - Exercise

KW - Fitness

KW - Hormones

KW - Prefrontal cortex

UR - http://www.scopus.com/inward/record.url?scp=33845426937&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845426937&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2005.11.016

DO - 10.1016/j.neurobiolaging.2005.11.016

M3 - Article

C2 - 16406152

AN - SCOPUS:33845426937

SN - 0197-4580

VL - 28

SP - 179

EP - 185

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 2

ER -

Interactive effects of fitness and hormone treatment on brain health in postmenopausal women

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this