Interactions in cytochrome oxidase: Functions and structure

Jo A. Freedman, Samuel H.P. Chan

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Mitochondrial cytochrome c oxidase is an exceedingly complex multistructural and multifunctional membranous enzyme. In this review, we will provide an overview of the many interactions of cytochrome oxidase, stressing developments not covered by the excellent monograph of Wikström, Krab, and Saraste (1981), and continuing into early 1983. First we describe its functions (both in the nominal sense, as a transporter of electrons between cytochrome c and oxygen, and in its role in energy transduction). Then we describe its structure, emphasizing the protein (its structure as a whole, the number and stoichiometry of its subunits, their biosynthetic origin, and their interactions with each other, with other components of the enzyme complex, and with the membrane as a whole). Finally, we present a model in which the protein conformation serves as the focus for the dynamic interaction of its two major functions.

Original languageEnglish (US)
Pages (from-to)75-100
Number of pages26
JournalJournal of Bioenergetics and Biomembranes
Issue number2
StatePublished - Apr 1984


  • Cytochrome oxidase
  • digenomic biosynthesis
  • electron transport
  • lipid-protein interactions
  • oxidative phosphorylation
  • structural-functional interactions

ASJC Scopus subject areas

  • Physiology
  • Cell Biology


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