Initial experimentation with in-line holography x-ray phase-contrast imaging with an ultrafast laser-based x-ray source

Andrzej Krol, Russell Kincaid, Marina Servol, Jean Claude Kieffer, Yakov Nesterets, Tim Gureyev, Andrew Stevenson, Steve Wilkins, Hongwei Ye, Edward Lipson, Remy Toth, Andrew Pogany, Ioana Coman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

We have investigated experimentally and theoretically the imaging performance of our newly constructed in-line holography x-ray phase-contrast imaging system with an ultrafast laser-based x-ray source. Projection images of nylon fibers with diameters in the 10-330 μm range were obtained using an ultrafast (100 Hz, 28 fs, 40 mJ) laser-based x-ray source with Mo and Ta targets and Be filter, and Gaussian spatial-intensity distribution (FWHMS = 5 μm). A cooled CCD camera (24 μm pitch) with a Gd 2OS 2 screen coupled via 1:1 optical taper was used (FWHMD = 50 μm). We have investigated nylon-fiber image quality vs. imaging setup geometry and x-ray spectra. The following parameters were evaluated: contrast, signal-to-noise ratio (SNR), resolution, and sampling. In addition, we performed theoretical simulation of image formation for the same objects but within a wide range of geometrical parameters. The rigorous wave-optical formalism was used for modeling of the free-space propagation of x-rays from the object plane to the detector, and the "projection approximation" was used. We found reasonable agreement between predictions of our analytical model and the experiments. We conclude that: a) Optimum magnification maximizing contrast and SNR is almost independent of the source-to-detector (R) distance and depends strongly on the diameter of the fiber, b) The corresponding maximum values of the contrast and SNR are almost linear with respect to R; the optimum magnification decreases with fiber diameter, c) The minimum diameter of fiber defines the minimum source-to-object distance R 1 if R is fixed and the object is moved.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2007
Subtitle of host publicationPhysics of Medical Imaging
EditionPART 1
DOIs
StatePublished - Oct 16 2007
EventMedical Imaging 2007: Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 18 2007Feb 22 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
NumberPART 1
Volume6510
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2007: Physics of Medical Imaging
CountryUnited States
CitySan Diego, CA
Period2/18/072/22/07

    Fingerprint

Keywords

  • In-line x-ray holography
  • Ultrafast laser-based x-ray source
  • X-ray phase-contrast imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Krol, A., Kincaid, R., Servol, M., Kieffer, J. C., Nesterets, Y., Gureyev, T., Stevenson, A., Wilkins, S., Ye, H., Lipson, E., Toth, R., Pogany, A., & Coman, I. (2007). Initial experimentation with in-line holography x-ray phase-contrast imaging with an ultrafast laser-based x-ray source. In Medical Imaging 2007: Physics of Medical Imaging (PART 1 ed.). [65100L] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6510, No. PART 1). https://doi.org/10.1117/12.713634