Inhibitors Targeting Human Ghrelin O-Acyltransferase

James Hougland (Inventor)

Research output: Patent


Grhelin O-acyltransferase inhibitors using a triazole linkage to incorporate aromatic and alkyl substituents to mimic the natural octanoyl group attached to ghrelin. Inhibitors include a triazole portion, an alkyl linker, and a hydrophobic aromatic group on a side chain. The hydrophobic aromatic group may include various length alkyl linkers.
Original languageEnglish (US)
Patent number9,340,578
StatePublished - Jul 15 2015


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