TY - JOUR
T1 - Inhibition of biofilm formation and swarming of Bacillus subtilis by (5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone
AU - Ren, D.
AU - Sims, J. J.
AU - Wood, T. K.
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Aims: (5Z)-4-Bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone (furanone) of the marine alga Delisea pulchra was synthesized, and its inhibition of swarming motility and biofilm formation of Bacillus subtilis was investigated. Methods and Results: Furanone was found to inhibit both the growth of B. subtilis and its swarming motility in a concentration-dependent way. In addition, as shown by confocal scanning laser microscopy, furanone inhibited the biofilm formation of B. subtilis. At 40 lg ml)1, furanone decreased the biofilm thickness by 25%, decreased the number of water channels, and reduced the percentage of live cells by 63%. Conclusions, Significance and Impact of the Study: Natural furanone has potential for controlling the multicellular behaviour of Gram-positive bacteria.
AB - Aims: (5Z)-4-Bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone (furanone) of the marine alga Delisea pulchra was synthesized, and its inhibition of swarming motility and biofilm formation of Bacillus subtilis was investigated. Methods and Results: Furanone was found to inhibit both the growth of B. subtilis and its swarming motility in a concentration-dependent way. In addition, as shown by confocal scanning laser microscopy, furanone inhibited the biofilm formation of B. subtilis. At 40 lg ml)1, furanone decreased the biofilm thickness by 25%, decreased the number of water channels, and reduced the percentage of live cells by 63%. Conclusions, Significance and Impact of the Study: Natural furanone has potential for controlling the multicellular behaviour of Gram-positive bacteria.
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U2 - 10.1046/j.1472-765x.2002.01087.x
DO - 10.1046/j.1472-765x.2002.01087.x
M3 - Article
C2 - 11940163
AN - SCOPUS:0036224155
SN - 0266-8254
VL - 34
SP - 293
EP - 299
JO - Letters in Applied Microbiology
JF - Letters in Applied Microbiology
IS - 4
ER -