Influences of a dietary supplement in combination with an exercise and diet regimen on adipocytokines and adiposity in women who are overweight

Maren S. Fragala, William J. Kraemer, Jeff S. Volek, Carl M. Maresh, Michael J. Puglisi, Jakob L. Vingren, Jen Yu Ho, Disa L. Hatfield, Barry A. Spiering, Cassandra E. Forsythe, Gwendolyn A. Thomas, Erin E. Quann, Jeffrey M. Anderson, Robert L. Hesslink

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The influence of a proprietary blend of modified cellulose and cetylated fatty acids (Trisynex™, Imagenetix, Inc., San Diego, CA 92127, USA) on adipocytokine and regional body composition responses to a weight loss program was examined. Twenty-two women (Supplement group (S) (n = 11): age = 36.8 ± 7.2 years; weight = 87.1 ± 6.2 kg; % body fat = 43.4 ± 4.1; Placebo group (P) (n = 11): age = 38.3 ± 6.8 years; weight = 86.9 ± 4.7 kg; % body fat = 44.3 ± 2.0) completed an 8-week placebo-controlled, double-blind study consisting of a caloric restricted diet and cardiovascular exercise. Body composition and serum insulin, leptin, and adiponectin were assessed at pre-, mid-, and post-intervention. From pre- to post-intervention, significant decreases (P < 0.05) were observed for body weight (S: 87.1 ± 6.2-77.9 ± 5.1 kg; P: 86.9 ± 4.7-82.7 ± 3.8 kg) (P < 0.05 S vs. P), % body fat (S: 43.4 ± 4.1-36.1 ± 3.6; P: 44.3 ± 2.0-40.6 ± 1.2) (P < 0.05 S vs. P), leptin (S: 28.3 ± 3.5-16.2 ± 2.6 ng ml-1; P: 29.4 ± 3.2-19.9 ± 1.1 ng ml-1) (P < 0.05 S vs. P), and insulin (S: 7.3 ± 0.8-5.1 ± 0.2 mU l-1; P: 7.7 ± 0.9-5.1 ± 0.3 mU l-1). Serum adiponectin increased (P < 0.05) (S: 12.2 ± 2.4-26.3 ± 3.0 μg ml-1: 12.6 ± 2.0-21.8 ± 3.1 μg ml-1) (P < 0.05 for S vs. P). Supplementation with a proprietary blend of modified cellulose and cetylated fatty acids during an 8-week weight loss program exhibited favorable effects on adipocytokines and regional body composition.

Original languageEnglish (US)
Pages (from-to)665-672
Number of pages8
JournalEuropean Journal of Applied Physiology
Volume105
Issue number5
DOIs
StatePublished - 2009

Keywords

  • Adipocytokines
  • Diet
  • Dietary supplement
  • Exercise
  • Weight loss

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)

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