Increases in extracellular fluid glucose levels in the rat hippocampus following an anesthetic dose of pentobarbital or ketamine-xylazine: An in vivo microdialysis study

Clinton E. Canal, Ewan C. McNay, Paul E. Gold

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Using in vivo microdialysis, we examined glucose levels in the extracellular fluid (ECF) of the hippocampus and in the blood prior to and during pentobarbital (45 mg/kg) or ketamine-xylazine (66 mg/kg, 7 mg/kg) anesthesia. Anesthesia with either pentobarbital or ketamine-xylazine significantly increased hippocampal ECF glucose levels (mean peak increases of +71% and +85%, respectively). In addition, there were substantial increases in blood glucose levels (mean peak increases of +24% and +30%, respectively). The increased levels of hippocampal ECF glucose during anesthesia complement past evidence for decreases in ECF glucose in the hippocampus observed while rats perform a memory task sensitive to hippocampal damage, providing further support for the view that ECF glucose levels in the hippocampus are dynamically coupled to local neural activity.

Original languageEnglish (US)
Pages (from-to)245-250
Number of pages6
JournalPhysiology and Behavior
Volume84
Issue number2
DOIs
StatePublished - Feb 15 2005
Externally publishedYes

Keywords

  • Anesthesia
  • Blood glucose
  • Brain glucose
  • Brain metabolism
  • Ketamine-xylazine
  • Pentobarbital

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Fingerprint Dive into the research topics of 'Increases in extracellular fluid glucose levels in the rat hippocampus following an anesthetic dose of pentobarbital or ketamine-xylazine: An in vivo microdialysis study'. Together they form a unique fingerprint.

  • Cite this