TY - JOUR
T1 - In vitro cardiac tissue models
T2 - Current status and future prospects
AU - Mathur, Anurag
AU - Ma, Zhen
AU - Loskill, Peter
AU - Jeeawoody, Shaheen
AU - Healy, Kevin E.
N1 - Funding Information:
This work was supported in part from the NIH R01HL096525 , UH2TR000487 , UH3TR000487 , and R21 EB21003 . A. M. is a postdoctoral fellow of CIRM training program TG2-01164. P. L. is supported by a postdoctoral fellowship from the German Research Foundation , LO 2081/1-1 . S. J. is supported by the National Science Foundation Graduate Research Fellowship DGE 1106400 .
Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2016/1/15
Y1 - 2016/1/15
N2 - Cardiovascular disease is the leading cause of death worldwide. Achieving the next phase of potential treatment strategies and better prognostic tools will require a concerted effort from interdisciplinary fields. Biomaterials-based cardiac tissue models are revolutionizing the area of preclinical research and translational applications. The goal of in vitro cardiac tissue modeling is to create physiological functional models of the human myocardium, which is a difficult task due to the complex structure and function of the human heart. This review describes the advances made in area of in vitro cardiac models using biomaterials and bioinspired platforms. The field has progressed extensively in the past decade, and we envision its applications in the areas of drug screening, disease modeling, and precision medicine.
AB - Cardiovascular disease is the leading cause of death worldwide. Achieving the next phase of potential treatment strategies and better prognostic tools will require a concerted effort from interdisciplinary fields. Biomaterials-based cardiac tissue models are revolutionizing the area of preclinical research and translational applications. The goal of in vitro cardiac tissue modeling is to create physiological functional models of the human myocardium, which is a difficult task due to the complex structure and function of the human heart. This review describes the advances made in area of in vitro cardiac models using biomaterials and bioinspired platforms. The field has progressed extensively in the past decade, and we envision its applications in the areas of drug screening, disease modeling, and precision medicine.
KW - Biomaterials
KW - Cardiac tissue models
KW - Disease modeling
KW - Drug screening
KW - In vitro cardiac tissue engineering
KW - Regenerative medicine
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=84951804391&partnerID=8YFLogxK
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U2 - 10.1016/j.addr.2015.09.011
DO - 10.1016/j.addr.2015.09.011
M3 - Review article
C2 - 26428618
AN - SCOPUS:84951804391
SN - 0169-409X
VL - 96
SP - 203
EP - 213
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
ER -