In vitro cardiac tissue models: Current status and future prospects

Anurag Mathur, Zhen Ma, Peter Loskill, Shaheen Jeeawoody, Kevin E. Healy

Research output: Contribution to journalReview article

70 Scopus citations

Abstract

Cardiovascular disease is the leading cause of death worldwide. Achieving the next phase of potential treatment strategies and better prognostic tools will require a concerted effort from interdisciplinary fields. Biomaterials-based cardiac tissue models are revolutionizing the area of preclinical research and translational applications. The goal of in vitro cardiac tissue modeling is to create physiological functional models of the human myocardium, which is a difficult task due to the complex structure and function of the human heart. This review describes the advances made in area of in vitro cardiac models using biomaterials and bioinspired platforms. The field has progressed extensively in the past decade, and we envision its applications in the areas of drug screening, disease modeling, and precision medicine.

Original languageEnglish (US)
Pages (from-to)203-213
Number of pages11
JournalAdvanced Drug Delivery Reviews
Volume96
DOIs
StatePublished - Jan 15 2016
Externally publishedYes

Keywords

  • Biomaterials
  • Cardiac tissue models
  • Disease modeling
  • Drug screening
  • In vitro cardiac tissue engineering
  • Regenerative medicine
  • Tissue engineering

ASJC Scopus subject areas

  • Pharmaceutical Science

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