Implementation OSEM mesh-domain SPECT reconstruction with explicit prior information

Andrzej Krol, Levon Vogelsang, Yao Lu, Yuesheng Xu, Xiaofei Hu, Lixin Shen, David Feiglin, Edward Lipson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In order to improve reconstructed image quality, we investigated performance of OSEM mesh-domain SPECT reconstruction with explicit prior anatomical and physiological information that was used to perform accurate attenuation compensation. It was accomplished in the following steps: (i) Obtain anatomical and physiological atlas of desired region of interest; (ii) Generate mesh that encodes properties of the atlas; (iii) Perform initial pixel-based reconstruction on projection dataset; (iv) Register the expected emission atlas to the initial pixel-based reconstruction and apply resulting transformation to meshed atlas; (v) Perform reconstruction in mesh-domain using deformed mesh of the atlas. This approach was tested on synthetic SPECT noise-free and noisy data. Comparative quantitative analysis demonstrated that this method outperformed pixel-based OSEM with uniform AC and is a promising approach that might lead to improved SPECT reconstruction quality

Original languageEnglish (US)
Title of host publicationMedical Imaging 2009
Subtitle of host publicationPhysics of Medical Imaging
DOIs
StatePublished - Jun 15 2009
EventMedical Imaging 2009: Physics of Medical Imaging - Lake Buena Vista, FL, United States
Duration: Feb 9 2009Feb 12 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7258
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2009: Physics of Medical Imaging
CountryUnited States
CityLake Buena Vista, FL
Period2/9/092/12/09

Keywords

  • Explicit prior knowledge incorporation
  • Mesh-domain SPECT image reconstruction

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Krol, A., Vogelsang, L., Lu, Y., Xu, Y., Hu, X., Shen, L., Feiglin, D., & Lipson, E. (2009). Implementation OSEM mesh-domain SPECT reconstruction with explicit prior information. In Medical Imaging 2009: Physics of Medical Imaging [72585C] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7258). https://doi.org/10.1117/12.813815