Implementation of a fully 3D system model for brain SPECT with fan-beam-collimator OSEM reconstruction with 3D total variation regularization

Ye Hongwei, Andrzej Krol, Edward D. Lipson, Lu Yao, Xu Yuesheng, Lee Wei, David H. Feiglin

Research output: Chapter in Book/Entry/PoemConference contribution

3 Scopus citations


In order to improve tomographically reconstructed image quality, we have implemented a fully 3D reconstruction, using an ordered subsets expectation maximization (OSEM) algorithm for fan-beam collimator (FBC) SPECT, along with a volumetric system model-fan-volume system model (FVSM), a modified attenuation compensation, a 3D depth- and angle-dependent resolution and sensitivity correction, and a 3D total variation (TV) regularization. SPECT data were acquired in a 128×64 matrix, in 120 views with a circular orbit. The numerical Zubal brain phantom was used to simulate a FBC HMPAO Tc-99m brain SPECT scan, and a low noise and scatter-free projection dataset was obtained using the SimSET Monte Carlo package. A SPECT scan for a mini-Defrise phantom and brain HMPAO SPECT scans for five patients were acquired with a triple-head gamma camera (Triad 88) equipped with a low-energy high-resolution (LEHR) FBC. The reconstructed images, obtained using clinical filtered back projection (FBP), OSEM with a linelength system model (LLSM) and 3D TV regularization, and OSEM with FVSM and 3D TV regularization were quantitatively studied. Overall improvement in the image quality has been observed, including better axial and transaxial resolution, better integral uniformity, higher contrast-to-noise ration between the gray matter and the white matter, and better accuracy and lower bias in OSEM-FVSM, compared with OSEM-LLSM and clinical FBP.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2007
Subtitle of host publicationPhysics of Medical Imaging
EditionPART 3
StatePublished - 2007
EventMedical Imaging 2007: Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 18 2007Feb 22 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
NumberPART 3
ISSN (Print)1605-7422


OtherMedical Imaging 2007: Physics of Medical Imaging
Country/TerritoryUnited States
CitySan Diego, CA


  • 3D total variation regularization
  • Fan-beam collimator
  • Fan-beam fully 3D reconstruction
  • HMPAO brain SPÉCT

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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