Impairment of spontaneous alternation performance by an nmda antagonist: attenuation with non-NMDA treatments

David L. Walker, Paul E. Gold

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

N-Methyl-d-aspartate (NMDA) receptor antagonists disrupt learning on a variety of tasks. Previous findings indicate that glucose, naloxone, and physostigmine ameliorate learning deficits produced by several treatments. The present experiment examines whether these agents also reverse the amnestic effects of NMDA receptor blockade. Mice were tested for spontaneous alternation performance in a Y-maze. The animals received either saline or the NMDA antagonist, NPC 12626 (35 mg/kg, IP), 50 min prior to testing and received an additional injection of saline, glucose, naloxone, or physostigmine 30 min prior to testing. NPC 12626 significantly decreased alternation scores. Glucose (250 mg/kg), physostigmine (0.01 mg/kg), and naloxone (1 mg/kg) reversed the effects of NPC 12626. Thus, impairments of learning after NMDA receptor blockade share with other anmestic conditions the susceptibility to attenuation by glucose, naloxone, and physostigmine.

Original languageEnglish (US)
Pages (from-to)69-71
Number of pages3
JournalBehavioral and Neural Biology
Volume58
Issue number1
DOIs
StatePublished - Jul 1992
Externally publishedYes

ASJC Scopus subject areas

  • Physiology

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