Impaired retention of visual discriminated escape training produced by subseizure amygdala stimulation

Paul Ernest Gold, Robert P. Rose, Linda L. Hankins, Curt Spanis

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

These experiments examined the effects on memory of posttrial, subseizure, electrical stimulation of the amygdala. Rats were trained in a visual discriminated avoidance Y-maze. Each animal received 6 trials on the training day. Retention, tested the following day, was measured both by the number of correct choices on the first 6 retraining trials and by the number of trials to a criterion of 5 of 6 correct choices. If administered 2 min, 1 h, or 4 h, but not 10 h, after training, bilateral amygdala stimulation significantly impaired retention as measured 24 h afteer training. In a second experiment, rats received unilateral amygdala stimulation in order to examine better the anatomical localization of effective stimulation sites. The unilateral stimulation was administered either 2 min, 10 min, 1 h, or 4 h after training. The behavioral procedures were the same as those used in the first experiment. For animals stimulated 2 min after training, the optimal stimulation region was one which extended rostrally from the ventrolateral portion of the basomedial nucleus to the dorsomedial region of the amygdala near the stria terminalis and nucleus centralis. For animals stimulated after a 10 min training-treatment interval, this amygdala region was not an effective site. However, in these animals, stimulation of the basolateral nucleus impaired later retention. Unilateral, posttraining amygdala stimulation administered 1 or 4 h after training did not appear to produce retention deficits. The findings of these experiments thus indicate that posttrial unilateral of bilateral amygdala stimulation impairs retention of discriminated avoidance training. Furthermore, the specific amygdala site at which posttrial stimulation impairs later retention varies with the training-treatment interval.

Original languageEnglish (US)
Pages (from-to)73-85
Number of pages13
JournalBrain Research
Volume118
Issue number1
DOIs
StatePublished - Dec 10 1976
Externally publishedYes

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Amygdala
Mediodorsal Thalamic Nucleus
Septal Nuclei
Retention (Psychology)
Electric Stimulation

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Impaired retention of visual discriminated escape training produced by subseizure amygdala stimulation. / Gold, Paul Ernest; Rose, Robert P.; Hankins, Linda L.; Spanis, Curt.

In: Brain Research, Vol. 118, No. 1, 10.12.1976, p. 73-85.

Research output: Contribution to journalArticle

Gold, Paul Ernest ; Rose, Robert P. ; Hankins, Linda L. ; Spanis, Curt. / Impaired retention of visual discriminated escape training produced by subseizure amygdala stimulation. In: Brain Research. 1976 ; Vol. 118, No. 1. pp. 73-85.
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