Identifying the important structural elements of brominated furanones for inhibiting biofilm formation by Escherichia coli

Yongbin Han, Shuyu Hou, Karen A. Simon, Dacheng Ren, Yan Yeung Luk

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

A collection of structurally closely related furanones was synthesized to identify the most important structural elements in brominated furanones for inhibiting the formation of bacterial biofilms. The results suggest that a conjugated exocyclic vinyl bromide on the furanone ring is the most important structural element for the non-toxic but inhibition activity for Escherichia coli biofilm formation. Furanones bearing monosubstituted bromide groups on saturated carbons were found to have a toxic effect that attenuates the bacterial growth.

Original languageEnglish (US)
Pages (from-to)1006-1010
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number3
DOIs
StatePublished - Feb 1 2008

Keywords

  • Biofilm inhibition
  • Brominated furanones
  • Escherichia coli
  • Radical

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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