Identification of 2‐(2′‐octenyl) succinic acid in urine

Giuseppe Giordano, Walter J. McMurray, Stephen F. Previs, Roy D. Welch, Piero Rinaldo

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

2‐(2′‐octenyl)succinic acid has been identified in urine samples from children investigated for a possible inherited metabolic disease. Its structural identification has been achieved by gas chromatography/mass spectrometry using both electron ionization and chemical ionization and by tandem mass spectrometry (MS/MS) using fast‐atom bombardment and high‐resolution electron‐ionization analyses of the molecular ion in a complex biological matrix. The localization of the double bond was obtained by interpretation of a unexpected rearrangement reaction occurring after dimethyl disulfide derivatization.

Original languageEnglish (US)
Pages (from-to)170-172
Number of pages3
JournalRapid Communications in Mass Spectrometry
Volume4
Issue number5
DOIs
StatePublished - May 1990

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Identification of 2‐(2′‐octenyl) succinic acid in urine'. Together they form a unique fingerprint.

  • Cite this