Hydrodynamic effects on the solute transport across endothelial pores and hepatocyte membranes

Dumitru Popescu, Liviu Movileanu, Stelian Ion, Maria Luiza Flonta

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

In this short note we propose a simple and rapid procedure to calculate the net quantity of metabolites absorbed by hepatocytes from blood plasma. The blood movement through sinusoids determines an opposed circulation of plasma through the space of Disse. Hydrodynamic considerations lead to the conclusion that hepatocytes absorb for their own synthesis processes a quantity of metabolites in a volume flow of the order of 10 -12 nl s-1 through a sieve plate surface with an area of 1 μm2. At pathological temperature (40°C), the excess of the net absorbed volume flow for the entire sinusoidal surface of the mammalian liver may be as high as 1.9 nl s-1. Some observations on the effect of red and white blood cells on the chylomicron traffic through endothelial pores are made.

Original languageEnglish (US)
Pages (from-to)N157-N165
JournalPhysics in Medicine and Biology
Volume45
Issue number11
DOIs
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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