Human basal body basics

Anastassiia Vertii, Hui Fang Hung, Heidi Hehnly, Stephen Doxsey

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

In human cells, the basal body (BB) core comprises a ninefold microtubule-triplet cylindrical structure. Distal and subdistal appendages are located at the distal end of BB, where they play indispensable roles in cilium formation and function. Most cells that arrest in the G0 stage of the cell cycle initiate BB docking at the plasma membrane followed by BB-mediated growth of a solitary primary cilium, a structure required for sensing the extracellular environment and cell signaling. In addition to the primary cilium, motile cilia are present in specialized cells, such as sperm and airway epithelium. Mutations that affect BB function result in cilia dysfunction. This can generate syndromic disorders, collectively called ciliopathies, for which there are no effective treatments. In this review, we focus on the features and functions of BBs and centrosomes in Homo sapiens.

Original languageEnglish (US)
Article number13
JournalCilia
Volume5
Issue number1
DOIs
StatePublished - Mar 14 2016

Keywords

  • Basal body
  • Centrosome
  • Ciliopathy
  • Cilium
  • Human

ASJC Scopus subject areas

  • Cell Biology

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  • Cite this

    Vertii, A., Hung, H. F., Hehnly, H., & Doxsey, S. (2016). Human basal body basics. Cilia, 5(1), [13]. https://doi.org/10.1186/s13630-016-0030-8