Host -guest interactions involving platinum anticancer agents. DNA binding and cytotoxicity of a β-cyclodextrin-adamantane-Pt(IV) complex

Yi Shi, James C. Dabrowiak

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A Pt(IV) complex, 1-adamantanemethylamine-Pt(IV), 2, a potential prodrug of the Pt(II) anticancer agent cisplatin was synthesized by tethering 1-adamantanemethylamine to oxoplatin using a dicarboxylate linker. The host-guest inclusion complex of 2 with β-cyclodextrin, is less toxic toward neuroblastoma SK-N-SH cells than cisplatin. Reduction of the inclusion complex with ascorbic acid produces a Pt(II) product that binds to and unwinds pBR322 form I DNA in a manner that is similar to that of cisplatin.

Original languageEnglish (US)
Pages (from-to)337-339
Number of pages3
JournalInorganica Chimica Acta
Volume393
DOIs
StatePublished - Dec 1 2012

    Fingerprint

Keywords

  • β-Cyclodextrin
  • Adamantane
  • Cytotoxicity
  • DNA binding
  • Host-guest
  • Platinum prodrug

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this