Abstract
A Pt(IV) complex, 1-adamantanemethylamine-Pt(IV), 2, a potential prodrug of the Pt(II) anticancer agent cisplatin was synthesized by tethering 1-adamantanemethylamine to oxoplatin using a dicarboxylate linker. The host-guest inclusion complex of 2 with β-cyclodextrin, is less toxic toward neuroblastoma SK-N-SH cells than cisplatin. Reduction of the inclusion complex with ascorbic acid produces a Pt(II) product that binds to and unwinds pBR322 form I DNA in a manner that is similar to that of cisplatin.
Original language | English (US) |
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Pages (from-to) | 337-339 |
Number of pages | 3 |
Journal | Inorganica Chimica Acta |
Volume | 393 |
DOIs | |
State | Published - Dec 1 2012 |
Keywords
- Adamantane
- Cytotoxicity
- DNA binding
- Host-guest
- Platinum prodrug
- β-Cyclodextrin
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Inorganic Chemistry
- Materials Chemistry