High-throughput biophysical measurement of human red blood cells

Yi Zheng, Ehsan Shojaei-Baghini, Azar Azad, Chen Wang, Yu Sun

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

This paper reports a micro system capable of performing biophysical measurements 011 human red blood cells (RBCs) both at a high speed (100-150 cells/second) and with a high throughput. Electrical impedance measurement is made when single human RBCs flow through a constriction channel that is marginally smaller than RBCs' diameters. The multiple parameters quantified as mechanical and electrical signatures of each RBC include transit time, impedance amplitude ratio, and impedance phase increase. Scatter plots compiled from 84.073 adult RBCs and 82.253 neonatal RBCs reveal different biophysical properties cross samples and between the adult and neonatal RBC populations.

Original languageEnglish (US)
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages398-400
Number of pages3
ISBN (Print)9780979806452
StatePublished - 2012
Externally publishedYes
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: Oct 28 2012Nov 1 2012

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Conference

Conference16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
Country/TerritoryJapan
CityOkinawa
Period10/28/1211/1/12

Keywords

  • Deformability
  • Electrical impedance
  • High throughput
  • Red blood cells

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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