TY - JOUR
T1 - Hepatitis E virus seroprevalence in three hyperendemic areas
T2 - Nepal, Bangladesh and southwest France
AU - Izopet, Jacques
AU - Labrique, Alain B.
AU - Basnyat, Buddha
AU - Dalton, Harry R.
AU - Kmush, Brittany
AU - Heaney, Christopher D.
AU - Nelson, Kenrad E.
AU - Ahmed, Zabed B.
AU - Zaman, K.
AU - Mansuy, Jean Michel
AU - Bendall, Richard
AU - Sauné, Karine
AU - Kamar, Nassim
AU - Arjyal, Amit
AU - Karkey, Abhilasha
AU - Dongol, Sabina
AU - Prajapati, Krishna Govind
AU - Adhikary, Dinesh
N1 - Publisher Copyright:
© 2015.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Background: Hepatitis E causes a significant burden of disease in developing countries and has recently been increasingly recognized in developed countries. Comparing population anti-hepatitis E virus (HEV) seroprevalence across populations has been difficult. Objectives: The aim of this study was to compare the anti-HEV IgG seroprevalence in both adults and children in three hyper-endemic areas (Nepal, Bangladesh and southwest France) using a sensitive, commercial anti-HEV IgG assay. Study Design: Serum or plasma from adults and children in Nepal (n=498), Bangladesh (. n=. 1,009) and Southwest France (. n=. 1031) were tested for anti-HEV IgG using the Wantai assay. Results: After age-standardization, anti-HEV IgG seroprevalence was 47.1%, 49.8% and 34.0% in Nepal, Bangladesh and southwest France, respectively. There was no difference in seroprevalence by gender in any of the countries. A paucity of infections in children 1-10 years-old was consistently observed (less than 15%) at all 3 locations. Conclusions: Surprisingly similar high rates of anti-HEV antibodies were detected using a common, sensitive assay. Despite differences in the epidemiology and circulating genotype of HEV in Nepal, Bangladesh and southwest France, this study found more similarities in population seroprevalence than expected.
AB - Background: Hepatitis E causes a significant burden of disease in developing countries and has recently been increasingly recognized in developed countries. Comparing population anti-hepatitis E virus (HEV) seroprevalence across populations has been difficult. Objectives: The aim of this study was to compare the anti-HEV IgG seroprevalence in both adults and children in three hyper-endemic areas (Nepal, Bangladesh and southwest France) using a sensitive, commercial anti-HEV IgG assay. Study Design: Serum or plasma from adults and children in Nepal (n=498), Bangladesh (. n=. 1,009) and Southwest France (. n=. 1031) were tested for anti-HEV IgG using the Wantai assay. Results: After age-standardization, anti-HEV IgG seroprevalence was 47.1%, 49.8% and 34.0% in Nepal, Bangladesh and southwest France, respectively. There was no difference in seroprevalence by gender in any of the countries. A paucity of infections in children 1-10 years-old was consistently observed (less than 15%) at all 3 locations. Conclusions: Surprisingly similar high rates of anti-HEV antibodies were detected using a common, sensitive assay. Despite differences in the epidemiology and circulating genotype of HEV in Nepal, Bangladesh and southwest France, this study found more similarities in population seroprevalence than expected.
KW - Adult
KW - Child
KW - Hepatitis E Virus
KW - Seroepidemiologic studies
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U2 - 10.1016/j.jcv.2015.06.103
DO - 10.1016/j.jcv.2015.06.103
M3 - Article
C2 - 26305817
AN - SCOPUS:84939620279
SN - 1386-6532
VL - 70
SP - 39
EP - 42
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
ER -